Buddecke E, Wollensak J
Fortschr Ophthalmol. 1989;86(5):502-8.
Proteoglycans are a family of protein polysaccharide conjugates that fulfill various functions in the macromolecular organization of the human eye. The high hydrodynamic volume of the proteoglycans, the large polyanionic domain of their polysaccharide chains, the specific primary structure of their protein moiety and their localization both on the cell surface and in the extracellular matrix enable the proteinglycans to regulate cell growth and development, assembly of the extracellular matrix components and cell-matrix and cell-cell interactions. Proteoglycans containing chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparan sulfate have been found to be structural and functional elements of the eye. This is exemplified by the corneal stroma, corneal endothelial cells, vitrous body, photoreceptor cells, and retinal pigment epithelium.
蛋白聚糖是一类蛋白质多糖共轭物，在人眼的大分子组织中发挥多种功能。蛋白聚糖具有高流体动力学体积、多糖链的大聚阴离子结构域、蛋白质部分的特定一级结构，以及它们在细胞表面和细胞外基质中的定位，这些使得蛋白聚糖能够调节细胞生长和发育、细胞外基质成分的组装以及细胞 - 基质和细胞 - 细胞相互作用。已发现含有硫酸软骨素、硫酸皮肤素、硫酸角质素和硫酸乙酰肝素的蛋白聚糖是眼睛的结构和功能元件。角膜基质、角膜内皮细胞、玻璃体、光感受器细胞和视网膜色素上皮就是例证。
