Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mol Cell. 2016 Feb 4;61(3):327-328. doi: 10.1016/j.molcel.2016.01.023.
In this issue of Molecular Cell, Bartolomei et al. (2016) describe a chromatin affinity precipitation method using well-characterized ADP-ribose binding domains to provide the first genome-wide view of ADP-ribosylated chromatin. Here, we discuss its potential applications and the remaining challenges ahead.
在本期《分子细胞》中，Bartolomei 等人（2016 年）描述了一种使用经过充分表征的 ADP-ribose 结合结构域的染色质亲和沉淀方法，从而首次提供了 ADP-ribosylated 染色质的全基因组视图。在这里，我们将讨论其潜在的应用和未来面临的挑战。
