Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea.
Cancer Lett. 2017 Feb 28;387:114-120. doi: 10.1016/j.canlet.2016.01.048. Epub 2016 Feb 2.
Liver metastasis is a leading cause of death in patients with colorectal cancer. Investigating the mechanisms of liver metastasis and control of disease progression are important strategies for improving survival of these patients. Liver metastasis is a multi-step process and relevant models representing these steps are necessary to understand the mechanism of liver metastasis and establish appropriate treatments. Recently, the development of animal models for use in metastasis research has greatly increased; however, there is still a lack of models that sufficiently represent human cancer. Thus, in order to select an optimal model for of a given study, it is necessary to fully understand the characteristics of each animal model. In this review, we describe the mouse models currently used for colorectal cancer with liver metastasis, their characteristics, and their pros and cons. This may help us specify the mechanism of liver metastasis and provide evidence relevant to clinical applications.
肝转移是结直肠癌患者死亡的主要原因。研究肝转移的机制和控制疾病进展是提高这些患者生存率的重要策略。肝转移是一个多步骤的过程，需要相关模型来代表这些步骤，以便了解肝转移的机制并建立适当的治疗方法。最近，用于转移研究的动物模型的发展有了很大的提高；然而，仍然缺乏能够充分代表人类癌症的模型。因此，为了选择给定研究的最佳模型，有必要充分了解每种动物模型的特点。在这篇综述中，我们描述了目前用于结直肠癌肝转移的小鼠模型及其特点和优缺点。这有助于我们明确肝转移的机制，并为临床应用提供相关证据。
