Gabory Anne, Chavatte-Palmer Pascale, Vambergue Anne, Tarrade Anne
Inra, UMR 1198 biologie du développement et reproduction, Domaine de Vilvert, F-78350 Jouy-en-Josas, France.
Inra, UMR 1198 biologie du développement et reproduction, Domaine de Vilvert, F-78350 Jouy-en-Josas, France - Fondation PremUp, 4, avenue de l'Observatoire, F-75006 Paris, France.
Med Sci (Paris). 2016 Jan;32(1):66-73. doi: 10.1051/medsci/20163201011. Epub 2016 Feb 5.
Located at the feto-maternal interface, the placenta is involved in exchange, endocrine and immune functions, which impact fetal development. In contact with the maternal environment, this organ is sensitive to metabolic disorders as over-nutrition, obesity or diabetes. The alteration of blood parameters associated with these pathologies affects placental histology, vascularization and nutrient transfers and, according to the types of troubles, induces local inflammation or hypoxia. These placental changes lead to disturbance of development and fetal growth, which increase the risk of pathologies in offspring in adulthood. The placenta thus appears as a crucial player in the fetal programming.
胎盘位于母胎界面，参与交换、内分泌和免疫功能，这些功能会影响胎儿发育。与母体环境接触，该器官对营养过剩、肥胖或糖尿病等代谢紊乱敏感。与这些病症相关的血液参数改变会影响胎盘组织学、血管形成和营养物质转运，并根据病症类型引发局部炎症或缺氧。这些胎盘变化会导致发育和胎儿生长紊乱，增加成年后代患病风险。因此，胎盘在胎儿编程中似乎起着关键作用。
