L-肌肽可预防衰老的腹膜间皮对卵巢癌细胞的促癌活性。
L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells.
作者信息
Mikuła-Pietrasik Justyna, Książek Krzysztof
机构信息
Department of Pathophysiology; Poznań University of Medical Sciences, Poznań, Poland.
Department of Pathophysiology; Poznań University of Medical Sciences, Poznań, Poland
出版信息
Anticancer Res. 2016 Feb;36(2):665-71.
BACKGROUND/AIM: L-Carnosine inhibits senescence of somatic cells and displays anticancer activity. Here we analyzed if L-carnosine (20 mM) retards senescence of human peritoneal mesothelial cells (HPMCs) and inhibits progression of ovarian cancer cells.
MATERIALS AND METHODS
Experiments were performed with primary HPMCs established from patients undergoing abdominal surgery and with three ovarian cancer cell lines: A2780, OVCAR-3 and SKOV-3.
RESULTS
L-Carnosine retards senescence of HPMCs plausibly via inhibition of mitochondria-related oxidative stress. Prolonged exposure of HPMCs to L-carnosine prevented senescent HPMC-dependent exacerbation of cancer cell adhesion, migration, invasion and proliferation, which may be linked with decreased secretion of various pro-cancerogenic agents by HPMCs. Cancer cells exposed directly to L-carnosine displayed reduced viability, increased frequency of apoptosis and unaltered proliferation.
CONCLUSION
L-carnosine may be a valuable anticancer drug, especially in the context of prevention and therapy of intraperitoneal ovarian cancer metastasis.
背景/目的：L-肌肽可抑制体细胞衰老并具有抗癌活性。在此，我们分析了L-肌肽（20 mM）是否会延缓人腹膜间皮细胞（HPMC）的衰老并抑制卵巢癌细胞的进展。
材料与方法
使用从接受腹部手术的患者中分离出的原代HPMC以及三种卵巢癌细胞系：A2780、OVCAR-3和SKOV-3进行实验。
结果
L-肌肽可能通过抑制线粒体相关的氧化应激来延缓HPMC的衰老。HPMC长期暴露于L-肌肽可防止衰老的HPMC依赖性癌细胞黏附、迁移、侵袭和增殖的加剧，这可能与HPMC分泌的各种促癌因子减少有关。直接暴露于L-肌肽的癌细胞活力降低，凋亡频率增加，增殖未改变。
结论
L-肌肽可能是一种有价值的抗癌药物，尤其是在预防和治疗腹膜内卵巢癌转移方面。
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