肌肽的抗癌作用：一种二肽分子。
Anti-Cancer Effects of Carnosine-A Dipeptide Molecule.
机构信息
Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.
Translational Immunology and Nanotechnology Research Program, School of Health and Biomedical Science, RMIT University, Melbourne, VIC 3083, Australia.
出版信息
Molecules. 2021 Mar 16;26(6):1644. doi: 10.3390/molecules26061644.
BACKGROUND
Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-cancer properties.
METHODS
In this study, we investigated the effect of carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation. We further examined U937 promonocytic, human myeloid leukemia cell phenotype, gene expression, and cytokine secretion to determine if these are linked to carnosine's anti-proliferative properties.
RESULTS
Carnosine (1) inhibits breast, ovarian, colon, and leukemic cancer cell proliferation; (2) upregulates expression of pro-inflammatory molecules; (3) modulates cytokine secretion; and (4) alters U937 differentiation and phenotype.
CONCLUSION
These effects may have implications for a role for carnosine in anti-cancer therapy.
背景
肌肽是一种二肽分子（β-丙氨酰-L-组氨酸），具有抗炎、抗氧化、抗糖基化和螯合特性。它在运动生理学中被用作食品补充剂来提高表现；然而，体外证据表明肌肽可能具有抗癌特性。
方法
在这项研究中，我们研究了肌肽对乳腺癌、卵巢癌、结肠癌和白血病癌细胞增殖的影响。我们进一步检查了 U937 前单核细胞、人类髓样白血病细胞表型、基因表达和细胞因子分泌，以确定这些是否与肌肽的抗增殖特性相关。
结果
肌肽（1）抑制乳腺癌、卵巢癌、结肠癌和白血病癌细胞的增殖；（2）上调促炎分子的表达；（3）调节细胞因子的分泌；和（4）改变 U937 的分化和表型。
结论
这些影响可能对肌肽在抗癌治疗中的作用具有重要意义。
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