腺样囊性癌可由 MYB 或 MYBL1 重排驱动：对 MYB 和肿瘤生物学的新认识。
Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology.
机构信息
School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.
Peter MacCallum Cancer Centre, the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Melbourne, Victoria, Australia.
出版信息
Cancer Discov. 2016 Feb;6(2):125-7. doi: 10.1158/2159-8290.CD-15-1470.
A majority of adenoid cystic carcinomas (AdCC)-rare tumors of the salivary gland and some other organs-have recently been found to be driven by chromosomal translocations resulting in MYB-NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways.
大多数腺样囊性癌（AdCC）——一种罕见的唾液腺和其他一些器官肿瘤——最近被发现是由染色体易位导致 MYB-NFIB 融合驱动的。Brayer 及其同事和 Mitani 及其同事现在报告称，AdCC 也可以由涉及第二个 MYB 家族基因 MYBL1 的类似重排驱动，并且这两个驱动因素的作用方式非常相似。
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