皮肤黑色素瘤、霍奇金淋巴瘤和非霍奇金淋巴瘤：共同的危险因素？

Cutaneous Melanoma, Hodgkin's Lymphoma and non-Hodgkin's Lymphoma: Common Risk Factors?

作者信息

Allam Mohamed Farouk, Serrano Pablo Fernández-Crehuet, Serrano José Luis Fernández-Crehuet, Abd Elaziz Khaled Mahmoud, Del Castillo Amparo Serrano, Navajas Rafael Fernández-Crehuet

机构信息

Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Cordoba, Cordoba, Spain.

Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

出版信息

Cent Eur J Public Health. 2015 Jun;23(2):119-21. doi: 10.21101/cejph.a4090.

DOI:10.21101/cejph.a4090

PMID:26851421

Abstract

AIM

An epidemiological cross-sectional study was conducted to evaluate the association between cutaneous melanoma, Hodgkin's lymphoma and non-Hodgkin's lymphoma in 40 European countries.

METHODS

Incidence rates were obtained from the database of the International Agency for Research of Cancer (IARC). We analyzed age-adjusted and gender-stratified incidence rates for cutaneous melanoma, Hodgkin's lymphoma and non-Hodgkin's lymphoma in 40 European countries. All European countries included had registration systems that fulfilled the quality criteria of IARC. Normal distribution of the variables was examined using Kolmorov-Smirnov test before calculating their correlations using Pearson's Correlation test.

RESULTS

In males, positive correlations were found between cutaneous melanoma, Hodgkin's lymphoma (r=0.14, p=0.38), and non-Hodgkin's lymphoma (r=0.64, p<0.001). In females, negative correlation was found between cutaneous melanoma and Hodgkin's lymphoma (r=0.28, p=0.08), however, positive correlation was found between cutaneous melanoma and non-Hodgkin's lymphoma (r=0.72, p<0.001).

CONCLUSION

Our findings raise the hypothesis about common risk factors for cutaneous melanoma and non-Hodgkin's lymphoma. New epidemiological and genetic studies are needed to identify possible common risk factors.

摘要

目的

开展一项流行病学横断面研究，以评估40个欧洲国家中皮肤黑色素瘤、霍奇金淋巴瘤和非霍奇金淋巴瘤之间的关联。

方法

发病率数据取自国际癌症研究机构（IARC）的数据库。我们分析了40个欧洲国家中皮肤黑色素瘤、霍奇金淋巴瘤和非霍奇金淋巴瘤的年龄调整发病率及按性别分层的发病率。所有纳入的欧洲国家均有符合IARC质量标准的登记系统。在使用Pearson相关检验计算变量之间的相关性之前，先使用Kolmorov-Smirnov检验检查变量的正态分布情况。

结果

在男性中，皮肤黑色素瘤与霍奇金淋巴瘤之间存在正相关（r = 0.14，p = 0.38），与非霍奇金淋巴瘤之间也存在正相关（r = 0.64，p < 0.001）。在女性中，皮肤黑色素瘤与霍奇金淋巴瘤之间存在负相关（r = 0.28，p = 0.08），然而，皮肤黑色素瘤与非霍奇金淋巴瘤之间存在正相关（r = 0.72，p < 0.001）。