Vipin Valam Putthussery, Dabadghao Preeti, Shukla Manoj, Kapoor Aditya, Raghuvanshi Arvind S, Ramesh Venkatraman
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Fertil Steril. 2016 May;105(5):1338-1344.e3. doi: 10.1016/j.fertnstert.2016.01.024. Epub 2016 Feb 4.
To assess the risk of cardiovascular disease (CVD) in the parents of polycystic ovary syndrome (PCOS) patients using carotid intima medial thickness (CIMT) and brachial artery flow-mediated dilatation (FMD).
Hospital-based case-control study.
Endocrine clinic of a medical institute in India.
PATIENT(S): Case group of 41 fathers and 45 mothers of PCOS patients (confirmed by Rotterdam's criteria) compared with 42 men and 44 women matched by age, sex and body mass index (BMI) as controls.
INTERVENTION(S): CVD risk in parents of PCOS patients assessed via CIMT and FMD then correlated with various clinical and metabolic parameters.
MAIN OUTCOME MEASURE(S): Differences in CIMT and FMD between parents and controls.
RESULT(S): The CIMT was higher [0.6 (0.54-0.8) vs. 0.5 (0.45-0.55) mm] and brachial artery FMD was lower [11.9% (6.9%-16.2%) vs. 16.7% (13.5%-22.6%)] in the parents of PCOS patients as compared with the controls. Systolic blood pressure, diastolic blood pressure, low-density lipoprotein cholesterol, and fasting and 2-hour plasma glucose were higher in the parents of the PCOS patients. The prevalence of CVD risk factors such as systemic hypertension, diabetes mellitus, abdominal obesity, the metabolic syndrome, and a family history of coronary artery disease in first-degree relatives was also higher in the parents of PCOS patients. The prevalence of diabetes was higher in the fathers of PCOS women, but other cardiovascular disease risk factors, CIMT, and FMD were comparable among the mothers.
CONCLUSION(S): The parents of PCOS patients have an increased CVD risk as evidenced by increased CIMT and low FMD.
采用颈动脉内膜中层厚度（CIMT）和肱动脉血流介导的血管舒张功能（FMD）评估多囊卵巢综合征（PCOS）患者父母患心血管疾病（CVD）的风险。
基于医院的病例对照研究。
印度一家医疗机构的内分泌门诊。
41名PCOS患者的父亲和45名母亲组成的病例组（根据鹿特丹标准确诊），与42名男性和44名女性对照，对照组按年龄、性别和体重指数（BMI）匹配。
通过CIMT和FMD评估PCOS患者父母的CVD风险，然后将其与各种临床和代谢参数进行关联。
父母与对照组之间CIMT和FMD的差异。
与对照组相比，PCOS患者父母的CIMT更高[0.6（0.54 - 0.8）mm对0.5（0.45 - 0.55）mm]，肱动脉FMD更低[11.9%（6.9% - 16.2%）对16.7%（13.5% - 22.6%）]。PCOS患者父母的收缩压、舒张压、低密度脂蛋白胆固醇、空腹及餐后2小时血糖更高。PCOS患者父母中，系统性高血压、糖尿病、腹型肥胖、代谢综合征以及一级亲属中有冠状动脉疾病家族史等CVD危险因素的患病率也更高。PCOS女性父亲的糖尿病患病率更高，但母亲中其他心血管疾病危险因素、CIMT和FMD相当。
PCOS患者父母患CVD的风险增加，CIMT升高和FMD降低证明了这一点。
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