Pradhan Jeeban, Mishra Ipsita, Rattan Roma, Choudhury Arun Kumar, Baliarsinha Anoj Kumar
Department of Endocrinology, S.C.B Medical College, Cuttack, Odisha, India.
Department of Biochemistry, S.C.B Medical College, Cuttack, Odisha, India.
J Hum Reprod Sci. 2022 Jul-Sep;15(3):250-258. doi: 10.4103/jhrs.jhrs_104_22. Epub 2022 Sep 30.
Polycystic ovary syndrome (PCOS) is a state of chronic low-grade inflammation. Low-grade inflammation has been linked to the development of cardiovascular disease (CVD). There is evidence of clustering for metabolic syndrome, hypertension, dyslipidaemia in type 2 diabetes mellitus and insulin resistance (IR) in mothers, fathers, sisters and brothers of women with PCOS.
The aim is to study the levels of inflammatory markers and IR in first-degree relatives of patients with PCOS and find any correlation with hormonal parameters, metabolic parameters and adiposity indices in them.
A total of 66 first-degree relatives of a patient with PCOS were included in this cross-sectional study.
All participants underwent detailed clinical evaluation and biochemical investigations, including high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), luteinising hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (only in females). Homeostasis model assessment of IR (HOMA-IR), lipid accumulation product and visceral adiposity index were calculated using standard equations. Visceral adipose tissue thickness and subcutaneous adipose tissue thickness were assessed using ultrasonography.
Spearman's and Pearson's correlation coefficients were used to analyse the correlation between different non-parametric and parametric data, respectively. Multiple linear regression was used to correlate multiple dependent factors.
The mean hs-CRP level was 2.4 ± 1.1 mg/L, which is greater than the cut-off of 2 mg/L and hs-CRP >2 mg/L was found in 62% ( = 41) participants. The mean IL-6 (3.5 ± 1.1 pg/ml) and total white blood cell count (7244 ± 2190/mm) were in the normal range. The mean HOMA-IR was 2.35 ± 0.76, which is elevated, considering HOMA IR >2 as a predictor of IR and metabolic syndrome. HOMA IR >2 was found in 64% ( = 42) of the participants. Inflammatory markers were significantly correlated with LH and HOMA IR, even after multiple linear regression was fitted for each marker individually.
Apparently, healthy first-degree relatives of PCOS patients had evidence of chronic low-grade inflammation. The chronic inflammation in them correlated well with HOMA-IR and LH but was independent of body mass index. This low-grade inflammation may predispose the first-degree relatives of PCOS to CVD.
多囊卵巢综合征（PCOS）是一种慢性低度炎症状态。低度炎症与心血管疾病（CVD）的发生有关。有证据表明，PCOS女性的母亲、父亲、姐妹和兄弟中存在代谢综合征、高血压、血脂异常以及2型糖尿病和胰岛素抵抗（IR）的聚集现象。
研究PCOS患者一级亲属的炎症标志物水平和IR，并找出其与激素参数、代谢参数和肥胖指数之间的相关性。
本横断面研究共纳入66名PCOS患者的一级亲属。
所有参与者均接受了详细的临床评估和生化检查，包括高敏C反应蛋白（hsCRP）、白细胞介素6（IL-6）、促黄体生成素（LH）、促卵泡生成素（FSH）和总睾酮（仅女性）。使用标准方程计算IR的稳态模型评估（HOMA-IR）、脂质蓄积产物和内脏肥胖指数。使用超声评估内脏脂肪组织厚度和皮下脂肪组织厚度。
分别使用Spearman和Pearson相关系数分析不同非参数和参数数据之间的相关性。使用多元线性回归分析多个相关因素。
hs-CRP平均水平为2.4±1.1mg/L，高于2mg/L的临界值，62%（n = 41）的参与者hs-CRP>2mg/L。IL-6平均水平（3.5±1.1pg/ml）和白细胞总数（7244±2190/mm）在正常范围内。HOMA-IR平均为2.35±0.76，考虑到HOMA IR>2作为IR和代谢综合征的预测指标，该值升高。64%（n = 42）的参与者HOMA IR>2。即使对每个标志物分别进行多元线性回归后，炎症标志物仍与LH和HOMA IR显著相关。
显然，PCOS患者健康的一级亲属有慢性低度炎症的证据。他们的慢性炎症与HOMA-IR和LH密切相关，但与体重指数无关。这种低度炎症可能使PCOS的一级亲属易患CVD。
