Udoh M O, Obaseki D E
Department of Pathology, University of Benin Teaching Hospital, PMB 1111, Benin-city, Nigeria.
East Afr Med J. 2012 Dec;89(12):408-13.
Endoscopic biopsy of the gastric mucosa allows early diagnosis, grading, staging and classification of gastric diseases. Helicobacter pylori, has been recognized as a major aetiologic factor for chronic gastritis, benign gastric ulcers and gastric adenocarcinoma and lymphoma. The loco-regional variability in the prevalence of Helicobacter pylori and associated diseases in Nigeria, emphasise the need for evaluation of subsets of a heterogeneous population like ours.
To determine the frequency of helicobacter pylori in gastric endoscopic biopsies and document the pathology of gastric lesions commonly associated with Helicobacter pylori infection.
Retrospective descriptive study.
University of Benin Teaching Hospital (UBTH), and Biogenics Histopathology Laboratory (a private Histopathology Laboratory), both based in Benin City, Niger Delta region of Nigeria.
Endoscopic gastric biopsies recorded in the surgical pathology register of the department from 2005-2009 were studied and relevant demographic and clinical information extracted from the registers, original request cards and patient case files. The clinical data and slides processed from paraffin embedded tissue blocks of endoscopic biopsies of gastric lesions seen from year 2005 to 2009 were studied, analyzed and statistically presented.
Total number of specimens studied was 142. Chronic gastritis was present in 117(82.39%) specimens; 9(6.34%) were benign gastric ulcers; 3(2.11%) were gastric polyps; and 11(7.75%) were gastric malignancies. Helicobacter pylori, was demonstrated in 55.6% of all specimens. The peak age for Chronic Gastritis and Gastric Cancer is the 6th decade. Amongst patients with chronic gastritis, inflammatory activity was present in 65%; atrophy in 53%; and intestinal metaplasia in 16.6%. All gastric malignancies seen were intestinal type adenocarcinomas.
The spectrum of lesions diagnosed in gastric endoscopic biopsy specimens in Benin, their frequency and associations are largely comparable to what has been described elsewhere in Nigeria and Africa.
胃黏膜内镜活检有助于对胃部疾病进行早期诊断、分级、分期及分类。幽门螺杆菌已被确认为慢性胃炎、良性胃溃疡、胃腺癌及淋巴瘤的主要病因。尼日利亚幽门螺杆菌及相关疾病患病率的局部地区差异，凸显了对像我们这样的异质人群亚组进行评估的必要性。
确定胃内镜活检中幽门螺杆菌的检出率，并记录与幽门螺杆菌感染常见相关的胃部病变的病理情况。
回顾性描述性研究。
贝宁大学教学医院（UBTH）以及生物基因组织病理学实验室（一家私立组织病理学实验室），二者均位于尼日利亚尼日尔三角洲地区的贝宁城。
对该科室手术病理登记册中2005年至2009年记录的胃内镜活检样本进行研究，并从登记册、原始申请卡及患者病历中提取相关人口统计学和临床信息。对2005年至2009年所见胃病变内镜活检石蜡包埋组织块处理后的临床数据及玻片进行研究、分析并进行统计学呈现。
共研究标本142例。117例（82.39%）标本存在慢性胃炎；9例（6.34%）为良性胃溃疡；3例（2.11%）为胃息肉；11例（7.75%）为胃恶性肿瘤。所有标本中55.6%检测出幽门螺杆菌。慢性胃炎和胃癌的发病高峰年龄在第6个十年。在慢性胃炎患者中，65%存在炎症活动；53%存在萎缩；16.6%存在肠化生。所有所见胃恶性肿瘤均为肠型腺癌。
在贝宁，胃内镜活检标本中诊断出的病变谱、其发生率及相关性与尼日利亚及非洲其他地方所描述的情况基本相当。
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