五例口腔孤立性纤维瘤新病例的临床病理及免疫组化特征
Clinicopathologic and immunohistochemical features of five new cases of solitary fibrous tumor of the oral cavity.
作者信息
Carlos Román, de Andrade Bruno Augusto Benevenuto, Canedo Nathalie Henriques Silva, Abrahão Aline Corrêa, Agostini Michelle, de Almeida Oslei Paes, Romañach Mário José
机构信息
Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
Department of Oral Diagnosis and Pathology, Federal University of Rio de Janeiro School of Dentistry, Rio de Janeiro, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Apr;121(4):390-5. doi: 10.1016/j.oooo.2015.11.001. Epub 2015 Nov 14.
OBJECTIVE
To describe the clinicopathologic and immunohistochemical features of five cases of oral solitary fibrous tumor.
STUDY DESIGN
Clinical data were collected from charts of two oral pathology laboratories of Latin America. All cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising vimentin, CD34, CD99, bcl-2, HHF-35, smooth muscle actin, calponin, S-100 protein, h-caldesmon, and Ki-67.
RESULTS
The study included 1 male (20%) and 4 female (80%) patients, with a median age of 43 years. The most common affected site was the buccal mucosa (40%). Tumors were characterized by proliferation of spindled and ovoid cells in a variably vascular and collagenized stroma. All tumors were positive for vimentin, CD34, bcl-2, and CD99. Recurrence was not observed after complete surgical enucleation.
CONCLUSIONS
Oral solitary fibrous tumors usually appear as well-delimited submucous nodules with a firm-rubbery consistency and covered by intact mucosa. Immunoreactivity for CD34, bcl-2, and CD-99 is helpful to confirm the diagnosis.
目的
描述5例口腔孤立性纤维瘤的临床病理及免疫组化特征。
研究设计
从拉丁美洲两个口腔病理实验室的病历中收集临床资料。所有病例均采用常规苏木精和伊红染色，并进行包括波形蛋白、CD34、CD99、bcl-2、HHF-35、平滑肌肌动蛋白、钙调蛋白、S-100蛋白、h-钙调蛋白和Ki-67的扩展免疫组化检测。
结果
该研究纳入1例男性患者（20%）和4例女性患者（80%），中位年龄43岁。最常见的受累部位是颊黏膜（40%）。肿瘤的特征是梭形和卵圆形细胞在不同程度血管化和胶原化的间质中增殖。所有肿瘤波形蛋白、CD34、bcl-2和CD99均呈阳性。完整手术摘除后未观察到复发。
结论
口腔孤立性纤维瘤通常表现为边界清晰的黏膜下结节，质地硬韧，表面黏膜完整。CD34、bcl-2和CD-99的免疫反应性有助于确诊。
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