O'Regan Esther M, Vanguri Vijay, Allen Carl M, Eversole Lewis Roy, Wright John M, Woo Sook-Bin
Oral Maxillofacial Pathology, Dublin Dental School and Hospital, Dublin, Ireland.
Head Neck Pathol. 2009 Jun;3(2):106-15. doi: 10.1007/s12105-009-0111-8. Epub 2009 Apr 28.
We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37-83). The most common locations included the buccal mucosa (the most common site), lip, maxillary or mandibular vestibule and tongue. Histopathologic examination showed well-circumscribed tumors with two well-defined patterns: the classic pattern with densely cellular areas alternating with hypocellular areas in a variably collagenous, vascular stroma and a more uniformly sclerotic pattern with only subtle classic areas. The spindle-shaped neoplastic cells consistently showed immunoreactivity for antibodies directed against CD34. Five of nineteen cases (26%) were reactive for CD99 and 19 of 19 for Bcl-2. Follow-up information was available in 17 cases and averaged 54 months, with no evidence of recurrence or metastasis in any of these patients. Awareness that solitary fibrous tumor may present in the oral cavity is important so that confusion with other spindle cell neoplasms can be avoided. We also briefly describe the differential diagnosis and compare this series, the largest single series of intraoral SFT, to cases previously reported in the literature.
我们描述了21例口腔孤立性纤维瘤的临床、形态学和免疫组化特征。患者中男性9例，女性12例，中位年龄51岁（范围37 - 83岁）。最常见的部位包括颊黏膜（最常见部位）、唇、上颌或下颌前庭以及舌。组织病理学检查显示肿瘤边界清晰，有两种明确的模式：经典模式，在不同程度胶原化、血管丰富的间质中，密集细胞区域与细胞稀少区域交替出现；以及更均匀硬化的模式，仅有细微的经典区域。梭形肿瘤细胞始终对针对CD34的抗体呈免疫反应性。19例中有5例（26%）对CD99呈反应性，19例中有19例对Bcl - 2呈反应性。17例有随访信息，平均随访时间为54个月，这些患者均无复发或转移迹象。认识到孤立性纤维瘤可能出现在口腔中很重要，这样可以避免与其他梭形细胞肿瘤混淆。我们还简要描述了鉴别诊断，并将这一最大的口腔内孤立性纤维瘤单一系列与文献中先前报道的病例进行了比较。
