Iochida L C, Tominaga M, Matsumoto M, Sekikawa A, Sasaki H
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Life Sci. 1989;45(17):1567-73. doi: 10.1016/0024-3205(89)90423-2.
Male Wistar rats weighing 250 +/- 30g were made septic by cecum ligation and perforation. Peripheral and hepatic sensitivity to insulin was assessed by the euglycemic glucose clamp technique with simultaneous [3H]glucose infusion. Hepatic glucose output was not suppressed by the insulin infusion in the septic rats in contrast with the controls. Glucose utilization by the peripheral tissues was not significantly different between the septic and control rats. Counterregulatory hormone levels were higher in the septic group. Our data suggest that the liver is the site of insulin resistance in the septic state.
体重为250±30克的雄性Wistar大鼠通过盲肠结扎和穿孔造成脓毒症。采用正常血糖葡萄糖钳夹技术并同时输注[3H]葡萄糖来评估外周和肝脏对胰岛素的敏感性。与对照组相比，脓毒症大鼠中胰岛素输注并未抑制肝脏葡萄糖输出。脓毒症大鼠与对照大鼠之间外周组织的葡萄糖利用率无显著差异。脓毒症组的对抗调节激素水平较高。我们的数据表明，肝脏是脓毒症状态下胰岛素抵抗的部位。
