朗格汉斯细胞组织细胞增多症：牙科领域的当前概念及病例报告

Langerhans cell histiocytosis: Current concepts in dentistry and case report.

作者信息

Ramos-Gutiérrez Efraín, Alejo-González Francisco, Ruiz-Rodríguez Socorro, Garrocho-Rangel José-Arturo, Pozos-Guillén Amaury

机构信息

DDS, Resident, Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, SLP, Mexico.

MD, MS, Associate Professor, Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, SLP, Mexico.

出版信息

J Clin Exp Dent. 2016 Feb 1;8(1):e102-8. doi: 10.4317/jced.52498. eCollection 2016 Feb.

DOI:10.4317/jced.52498

PMID:26855698

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4739360/

Abstract

UNLABELLED

Langerhans cell histiocytosis (LCH), which is a rare granulomatous pediatric disease of unknown etiology, is characterized by the idiopathic proliferation and accumulation of abnormal and clonal Langerhans cells or their marrow precursors, resulting in localized, solitary or multiple destructive lesions. These lesions are most commonly eosinophilic granuloma, which are found in craniofacial bone structures such as the skull and mandible, skin and other organs. In children, the disease has a variable initial presentation, and the clinical course, prognosis and survival are unpredictable. The aims of this report were to present an LCH case in a girl aged 2 years, 8 months and her clinicopathological features, to describe the bucodental management provided, and to discuss special dental considerations of this disease.

KEY WORDS

Children, dental management, histiocytosis, Langerhans cells.

摘要

朗格汉斯细胞组织细胞增多症（LCH）是一种病因不明的罕见小儿肉芽肿性疾病，其特征为异常克隆性朗格汉斯细胞或其骨髓前体细胞的特发性增殖和积聚，导致局部、单发或多发的破坏性病变。这些病变最常见的是嗜酸性肉芽肿，见于颅骨和下颌骨等颅面骨结构、皮肤及其他器官。在儿童中，该病初始表现多样，临床病程、预后及生存率难以预测。本报告旨在介绍一名2岁8个月女童的LCH病例及其临床病理特征，描述所采取的口腔牙科治疗措施，并讨论该疾病的特殊牙科注意事项。