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口腔健康教育与尼古丁替代疗法对戒烟的有效性——一项平行随机临床试验

Effectiveness of oral health education versus nicotine replacement therapy for tobacco cessation- a parallel randomized clinical trial.

作者信息

Raja Mitali, Saha Sabyasachi, Krishna-Reddy Vamsi, Mohd Shafaat, Narang Ridhi, Sood Poonam

机构信息

Senior Lecturer, Department of Public Health Dentistry, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh.

Professor and Head, Department of Public Health Dentistry, Sardar Patel Postgraduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh.

出版信息

J Clin Exp Dent. 2016 Feb 1;8(1):e64-70. doi: 10.4317/jced.52738. eCollection 2016 Feb.

DOI:10.4317/jced.52738
PMID:26855709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4739371/
Abstract

BACKGROUND

India has millions of tobacco users. It is the leading cause of deaths due to oral cancer and hence needs effective strategies to curb it. Hence the aim of present study was to evaluate and compare the effectiveness of Oral Health Education (OHE) and Nicotine Replacement Therapy (NRT) in tobacco cessation.

MATERIAL AND METHODS

The clinical trial consisted of Manohar Lal Kapoor (MLK) factory workers (n= 40) giving history of tobacco consumption (smoking/smokeless) within past 30 days. They were randomized into OHE (n=20) and NRT (n=20) groups. Baseline evaluation (demographic, smoking/ smokeless behaviour) was done. Fagerstrom test was used for Nicotine Dependence (FTND) and to assess nicotine addiction level. Follow up was done at an interval of 1week, 2 weeks, 1 month, 2 months and 3 months to assess the reduction in the mean FTND score. "Nano-CheckTM Rapid Nicotine test" was used for the qualitative detection of cotinine in human urine. Appropriate statistical analysis was performed (Paired and Unpaired t test).

RESULTS

In both OHE and NRT group there was a significant reduction (p< 0.00001) in mean Fagerstrom score at every follow up but when both the groups were compared mean Fagerstrom score reduction was more in NRT than OHE at all time interval though it was not statistically significant (p>0.05).

CONCLUSIONS

NRT is better than OHE when both the groups were compared. However, it was found that any intervention given to tobacco users either NRT or OHE is helpful for the patients in the process of quitting tobacco.

KEY WORDS

Tobacco cessation, nicotine replacement therapy, oral health education, fagerstrom test, urine cotinine.

摘要

背景

印度有数以百万计的烟草使用者。它是口腔癌致死的主要原因,因此需要有效的策略来加以遏制。所以本研究的目的是评估和比较口腔健康教育(OHE)和尼古丁替代疗法(NRT)在戒烟方面的效果。

材料与方法

该临床试验纳入了过去30天内有烟草消费(吸烟/无烟烟草)史的马诺哈尔·拉尔·卡普尔(MLK)工厂工人(n = 40)。他们被随机分为OHE组(n = 20)和NRT组(n = 20)。进行了基线评估(人口统计学、吸烟/无烟烟草行为)。使用法格斯特龙测试(FTND)来评估尼古丁依赖程度和尼古丁成瘾水平。每隔1周、2周、1个月、2个月和3个月进行随访,以评估平均FTND评分的降低情况。使用“Nano-CheckTM快速尼古丁测试”对人尿液中的可替宁进行定性检测。进行了适当的统计分析(配对和非配对t检验)。

结果

在每次随访时,OHE组和NRT组的平均法格斯特龙评分均有显著降低(p < 0.00001),但在比较两组时,尽管差异无统计学意义(p > 0.05),但在所有时间间隔内,NRT组的平均法格斯特龙评分降低幅度均大于OHE组。

结论

比较两组时,NRT比OHE更好。然而,研究发现,给予烟草使用者的任何干预措施,无论是NRT还是OHE,在帮助患者戒烟过程中都是有益的。

关键词

戒烟、尼古丁替代疗法、口腔健康教育、法格斯特龙测试、尿可替宁

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ad0/4739371/7b878472da66/jced-8-e64-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ad0/4739371/7b878472da66/jced-8-e64-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ad0/4739371/7b878472da66/jced-8-e64-g001.jpg

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