Smart CARS: optimized development of a chimeric antigen receptor (CAR) T cell targeting epidermal growth factor receptor variant III (EGFRvIII) for glioblastoma.
作者信息
Ruella Marco, Levine Bruce L
机构信息
1 Center for Cellular Immunotherapies, 2 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, 3 Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104-5157, USA.
出版信息
Ann Transl Med. 2016 Jan;4(1):13. doi: 10.3978/j.issn.2305-5839.2015.10.11.
Abstract
摘要
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Sci Transl Med. 2015 Sep 2;7(303):303ra139. doi: 10.1126/scitranslmed.aac5415.
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Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice.亲和力优化的ErbB2或EGFR嵌合抗原受体T细胞对小鼠肿瘤的治疗指数有所提高。
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Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity.调节嵌合抗原受体（CAR）对表皮生长因子受体（EGFR）密度的敏感性可在维持强大抗肿瘤活性的同时限制对正常组织的识别。
Cancer Res. 2015 Sep 1;75(17):3505-18. doi: 10.1158/0008-5472.CAN-15-0139.
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Sci Transl Med. 2015 Feb 18;7(275):275ra22. doi: 10.1126/scitranslmed.aaa4963.
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N Engl J Med. 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222.
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Immunotherapy. 2014;6(6):679-90. doi: 10.2217/imt.14.21.
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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.化疗难治性弥漫性大B细胞淋巴瘤和惰性B细胞恶性肿瘤可以用表达抗CD19嵌合抗原受体的自体T细胞进行有效治疗。
J Clin Oncol. 2015 Feb 20;33(6):540-9. doi: 10.1200/JCO.2014.56.2025. Epub 2014 Aug 25.
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T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.表达嵌合抗原受体的 T 细胞可导致人类过敏反应。
Cancer Immunol Res. 2013 Jul;1(1):26-31. doi: 10.1158/2326-6066.CIR-13-0006. Epub 2013 Apr 7.
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