作为诊断为铅中毒儿童铅暴露和毒性生物标志物的X射线荧光测定骨铅（Pb）
XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.
作者信息
Specht Aaron J, Lin Yanfen, Weisskopf Marc, Yan Chonghuai, Hu Howard, Xu Jian, Nie Linda H
机构信息
a School of Health Sciences , Purdue University , West Lafayette, IN , USA .
b Xinhua Hospital, MOE-Shanghai Key Laboratory of Children's Environmental Health, Department of Child and Adolescent Healthcare , Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine , Shanghai , China .
出版信息
Biomarkers. 2016;21(4):347-52. doi: 10.3109/1354750X.2016.1139183. Epub 2016 Feb 9.
Abstract
Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.
摘要
儿童铅中毒仍然是一个全球性问题，尤其是在工业区。在本研究中，115名平均年龄为5.7岁的儿童在中国新华医院被招募为铅中毒诊断患者或对照组。用K壳层X射线荧光（KXRF）和便携式X射线荧光（XRF）系统测量受试者的骨铅。观察到KXRF骨铅与血铅之间以及便携式XRF与KXRF测量值之间存在显著相关性。计算出血铅的半衰期为9.96±3.92天。我们的结果表明，骨骼是儿童铅的一种有用生物标志物。
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