Rosen J F, Crocetti A F, Balbi K, Balbi J, Bailey C, Clemente I, Redkey N, Grainger S
Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467.
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2789-92. doi: 10.1073/pnas.90.7.2789.
Measurements of lead (Pb) in bone reflect cumulative Pb exposure, whereas blood Pb levels are indices of absorption during the previous 21-30 days. This study was undertaken to estimate bone Pb concentrations by L-line x-ray fluorescence (LXRF) in a United States suburban population which was exposed to unusually high levels of Pb in emissions from an adjacent factory during 1963-1981, compared with concentrations similarly estimated in a matched suburban community without unusual Pb exposure. The mean bone Pb value in 269 residents of the highly exposed suburb (15 ppm) was 3-fold greater than that of the reference suburb (5 ppm). LXRF estimates of bone Pb identified those individuals at risk for adverse effects of Pb, whereas blood Pb levels were uninformative. Average LXRF-estimated bone Pb concentrations in residents of the unusually exposed suburb approximated estimated values in workers at Pb-processing factories.
骨骼中铅（Pb）的测量反映了铅的累积暴露情况，而血铅水平则是前21至30天内铅吸收情况的指标。本研究旨在通过L线X射线荧光（LXRF）法估算美国一个郊区人群的骨骼铅浓度。该人群在1963年至1981年期间受到相邻工厂排放的异常高水平铅的影响，并将其与在一个没有异常铅暴露的匹配郊区社区中同样估算出的浓度进行比较。在铅暴露水平高的郊区，269名居民的骨骼铅平均含量（15 ppm）是对照郊区（5 ppm）的3倍。LXRF对骨骼铅的估算能够识别出有铅不良反应风险的个体，而血铅水平则无法提供有效信息。在异常暴露郊区居民中，通过LXRF估算的骨骼铅平均浓度接近铅加工厂工人的估算值。
