体外评估棘白菌素类抗真菌药物对念珠菌属的药效动力学模型
In vitro pharmacodynamic modelling of anidulafungin against Candida spp.
机构信息
Departamento de Inmunología, Microbiología y Parasitología, Unidad de formación e investigación multidisciplinar 'Microbios y Salud' (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain; Departamento de Farmacología, (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.
Departamento de Farmacología, (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.
出版信息
Int J Antimicrob Agents. 2016 Mar;47(3):178-83. doi: 10.1016/j.ijantimicag.2015.12.011. Epub 2016 Jan 15.
The aim of this study was to fit anidulafungin in vitro static time-kill data from nine strains of Candida with a pharmacodynamic (PD) model in order to describe the antifungal activity of this drug against Candida spp. Time-kill data from strains of Candida albicans, Candida glabrata and Candida parapsilosis clades were best fit using an adapted sigmoidal Emax model and resulted in a set of PD parameters (Emax, EC50 and Hill factor) for each fungal strain. The data were analysed with NONMEM 7. Anidulafungin was effective in a species- and concentration-dependent manner against the strains of C. glabrata and C. parapsilosis clades as observed with the EC50 estimates. Maximum killing rate constant (Emax) values were higher against C. glabrata and C. parapsilosis complex strains. In conclusion, we demonstrated that the activity of anidulafungin against Candida can be accurately described using an adapted sigmoidal Emax model.
本研究旨在通过药效动力学（PD）模型拟合 9 株念珠菌的体外安尼拉fungin 静态杀菌数据，以描述该药物对念珠菌属的抗真菌活性。使用改良的 sigmoidal Emax 模型拟合白色念珠菌、光滑念珠菌和近平滑念珠菌属念珠菌的杀菌数据，为每种真菌菌株产生了一组 PD 参数（Emax、EC50 和 Hill 因子）。使用 NONMEM 7 对数据进行分析。观察到 EC50 估计值，安尼拉fungin 对 C. glabrata 和 C. parapsilosis 属念珠菌菌株具有浓度依赖性和种属依赖性的有效性。最大杀菌速率常数（Emax）值对 C. glabrata 和 C. parapsilosis 复合菌株更高。总之，我们证明了使用改良的 sigmoidal Emax 模型可以准确描述安尼拉fungin 对念珠菌的活性。
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