通过时间-杀菌研究评估阿尼芬净、卡泊芬净和米卡芬净对光滑念珠菌、布拉氏念珠菌和尼瓦念珠菌的体外杀菌活性。
In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.
作者信息
Gil-Alonso Sandra, Jauregizar Nerea, Cantón Emilia, Eraso Elena, Quindós Guillermo
机构信息
Departamento de Inmunología, Microbiología y Parasitología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain Departamento de Farmacología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.
Departamento de Farmacología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.
出版信息
Antimicrob Agents Chemother. 2015;59(6):3615-8. doi: 10.1128/AAC.04474-14. Epub 2015 Mar 23.
Abstract
Anidulafungin, caspofungin, and micafungin killing activities against Candida glabrata, Candida bracarensis, and Candida nivariensis were evaluated by the time-kill methodology. The concentrations assayed were 0.06, 0.125, and 0.5 μg/ml, which are achieved in serum. Anidulafungin and micafungin required between 13 and 26 h to reach the fungicidal endpoint (99.9% killing) against C. glabrata and C. bracarensis. All echinocandins were less active against C. nivariensis.
摘要
采用时间杀菌法评估了阿尼芬净、卡泊芬净和米卡芬净对光滑念珠菌、布拉氏念珠菌和 nivariensis 念珠菌的杀菌活性。所测定的浓度为 0.06、0.125 和 0.5 μg/ml，这些浓度可在血清中达到。阿尼芬净和米卡芬净对光滑念珠菌和布拉氏念珠菌达到杀菌终点（杀灭 99.9%）需要 13 至 26 小时。所有棘白菌素对 nivariensis 念珠菌的活性较低。
相似文献
1
In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.通过时间-杀菌研究评估阿尼芬净、卡泊芬净和米卡芬净对光滑念珠菌、布拉氏念珠菌和尼瓦念珠菌的体外杀菌活性。
Antimicrob Agents Chemother. 2015;59(6):3615-8. doi: 10.1128/AAC.04474-14. Epub 2015 Mar 23.
2
Examination of the in vitro fungicidal activity of echinocandins against Candida lusitaniae by time-killing methods.用时间杀菌法检测棘白菌素类对葡萄牙念珠菌的体外杀菌活性。
J Antimicrob Chemother. 2013 Apr;68(4):864-8. doi: 10.1093/jac/dks489. Epub 2012 Dec 9.
3
Comparative effects of micafungin, caspofungin, and anidulafungin against a difficult-to-treat fungal opportunistic pathogen, Candida glabrata.比较米卡芬净、卡泊芬净和阿尼芬净对一种难以治疗的真菌性机会致病菌光滑念珠菌的疗效。
Antimicrob Agents Chemother. 2012 Mar;56(3):1215-22. doi: 10.1128/AAC.05872-11. Epub 2011 Dec 27.
4
In vitro activities of echinocandins against Candida krusei determined by three methods: MIC and minimal fungicidal concentration measurements and time-kill studies.通过三种方法测定棘白菌素对克柔念珠菌的体外活性：最小抑菌浓度（MIC）和最小杀菌浓度测定以及时间杀菌研究。
Antimicrob Agents Chemother. 2009 Jul;53(7):3108-11. doi: 10.1128/AAC.00160-09. Epub 2009 Apr 20.
5
6
In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.体外杀菌活性的棘白菌素类药物对念珠菌属 metapsilosis 、 C. orthopsilosis 和 C. parapsilosis 通过时间杀死研究评估。
Antimicrob Agents Chemother. 2010 May;54(5):2194-7. doi: 10.1128/AAC.01538-09. Epub 2010 Feb 9.
7
In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates.念珠菌属侵袭性分离株的体外药敏情况：氟康唑敏感剂量依赖性光滑念珠菌分离株的比例迅速上升。
Antimicrob Agents Chemother. 2008 Aug;52(8):2919-22. doi: 10.1128/AAC.00323-08. Epub 2008 May 5.
8
Susceptibility to echinocandins of Candida spp. strains isolated in Italy assessed by European Committee for Antimicrobial Susceptibility Testing and Clinical Laboratory Standards Institute broth microdilution methods.采用欧洲抗菌药物敏感性试验委员会和临床实验室标准协会肉汤微量稀释法评估意大利分离的念珠菌属菌株对棘白菌素类药物的敏感性。
BMC Microbiol. 2015 May 20;15:106. doi: 10.1186/s12866-015-0442-4.
9
Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations.通过体内药效学评估优化棘白菌素类药物剂量和敏感性折点判断方法，用于治疗有或无 fks 突变的光滑念珠菌感染。
Antimicrob Agents Chemother. 2012 Nov;56(11):5875-82. doi: 10.1128/AAC.01102-12. Epub 2012 Sep 4.
10
Anidulafungin and micafungin MIC breakpoints are superior to that of caspofungin for identifying FKS mutant Candida glabrata strains and Echinocandin resistance.阿尼芬净和米卡芬净的 MIC 折点优于卡泊芬净，可用于鉴定 FKS 突变的光滑念珠菌菌株和棘白菌素耐药性。
Antimicrob Agents Chemother. 2013 Dec;57(12):6361-5. doi: 10.1128/AAC.01451-13. Epub 2013 Sep 23.
引用本文的文献
1
Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of : A European Study.伊柏昔芬（SCY-078）对来自有医学相关性的曲霉菌属种的当代血培养分离株的抗真菌活性：一项欧洲研究。
Front Cell Infect Microbiol. 2022 May 16;12:906563. doi: 10.3389/fcimb.2022.906563. eCollection 2022.
2
Candidiasis by , and in : Virulence and Therapeutic Responses to Echinocandins.白色念珠菌、光滑念珠菌和热带念珠菌引起的念珠菌病：对棘白菌素的毒力及治疗反应
J Fungi (Basel). 2021 Nov 23;7(12):998. doi: 10.3390/jof7120998.
3
In Vitro Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Amphotericin B against .两性霉素B的体外药代动力学/药效学建模与模拟 针对……
Pharmaceutics. 2021 Oct 22;13(11):1767. doi: 10.3390/pharmaceutics13111767.
4
Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells.通过耐药物细胞的转录组分析揭示了线粒体在棘白菌素类药物耐受中的多因素作用。
mBio. 2021 Aug 31;12(4):e0195921. doi: 10.1128/mBio.01959-21. Epub 2021 Aug 10.
5
In Vitro Synergistic Interactions of Isavuconazole and Echinocandins against .艾沙康唑与棘白菌素类药物对……的体外协同相互作用
Antibiotics (Basel). 2021 Mar 28;10(4):355. doi: 10.3390/antibiotics10040355.
6
Identification of Growth Inhibitors of the Fish Pathogen Using Subtractive Proteomics, Computational Modeling, and Biochemical Validation.利用消减蛋白质组学、计算建模和生化验证鉴定鱼类病原体的生长抑制剂
Front Microbiol. 2020 Oct 16;11:571093. doi: 10.3389/fmicb.2020.571093. eCollection 2020.
7
Rezafungin-Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins.瑞扎芬净的作用机制、敏感性及耐药性：与其他棘白菌素类药物的异同
J Fungi (Basel). 2020 Nov 1;6(4):262. doi: 10.3390/jof6040262.
8
Caenorhabditis elegans as a Model System To Assess Candida glabrata, , and Virulence and Antifungal Efficacy.秀丽隐杆线虫作为评估光滑念珠菌、 、 毒力和抗真菌疗效的模型系统。
（注：原文中存在部分缺失内容，已按实际翻译）
Antimicrob Agents Chemother. 2020 Sep 21;64(10). doi: 10.1128/AAC.00824-20.
9
Activity of Fenticonazole against and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays.芬替康唑对单一或混合物种检测试验中分离的 和细菌性阴道病的活性。
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.02693-18. Print 2019 Jul.
10
Therapeutic tools for oral candidiasis: Current and new antifungal drugs.口腔念珠菌病的治疗工具：当前及新型抗真菌药物
Med Oral Patol Oral Cir Bucal. 2019 Mar 1;24(2):e172-e180. doi: 10.4317/medoral.22978.
本文引用的文献
1
Epidemiology of candidaemia and invasive candidiasis. A changing face.念珠菌血症和侵袭性念珠菌病的流行病学。面貌正在改变。
Rev Iberoam Micol. 2014 Jan-Mar;31(1):42-8. doi: 10.1016/j.riam.2013.10.001. Epub 2013 Nov 19.
2
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?使用CLSI和EUCAST方法检测念珠菌属对卡泊芬净的最低抑菌浓度（MIC）的实验室间变异性：临床实验室是否应该检测这种药物？
Antimicrob Agents Chemother. 2013 Dec;57(12):5836-42. doi: 10.1128/AAC.01519-13. Epub 2013 Sep 9.
3
Inhibitory and fungicidal effects of antifungal drugs against Aspergillus species in the presence of serum.抗真菌药物在血清存在下对曲霉菌属的抑制和杀菌作用。
Antimicrob Agents Chemother. 2013 Apr;57(4):1625-31. doi: 10.1128/AAC.01573-12. Epub 2013 Jan 14.
4
Examination of the in vitro fungicidal activity of echinocandins against Candida lusitaniae by time-killing methods.用时间杀菌法检测棘白菌素类对葡萄牙念珠菌的体外杀菌活性。
J Antimicrob Chemother. 2013 Apr;68(4):864-8. doi: 10.1093/jac/dks489. Epub 2012 Dec 9.
5
[First case report of catheter-related fungemia by Candida nivariensis in the Iberian Peninsula].[伊比利亚半岛首例光滑念珠菌引起的导管相关真菌血症病例报告]
Rev Iberoam Micol. 2013 Jan 3;30(1):69-71. doi: 10.1016/j.riam.2012.09.001. Epub 2012 Sep 14.
6
Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey.一项西班牙多中心前瞻性调查：血流真菌感染的流行病学、菌种分布和体外抗真菌药敏性。
J Antimicrob Chemother. 2012 May;67(5):1181-7. doi: 10.1093/jac/dks019. Epub 2012 Feb 20.
7
Post-antifungal effects and time-kill studies of anidulafungin, caspofungin, and micafungin against Candida glabrata and Candida parapsilosis.棘白菌素类药物（安尼卡宾、卡泊芬净和米卡芬净）对光滑念珠菌和近平滑念珠菌的抗真菌后效应和时间杀菌研究。
Diagn Microbiol Infect Dis. 2011 Oct;71(2):131-8. doi: 10.1016/j.diagmicrobio.2011.06.018. Epub 2011 Aug 23.
8
Prevalence and antifungal susceptibility patterns of new cryptic species inside the species complexes Candida parapsilosis and Candida glabrata among blood isolates from a Spanish tertiary hospital.在西班牙一家三级医院的血液分离株中，副念珠菌和光滑念珠菌种内复合群中新隐球菌种的流行情况及抗真菌药敏模式。
J Antimicrob Chemother. 2011 Oct;66(10):2315-22. doi: 10.1093/jac/dkr298. Epub 2011 Jul 26.
9
Time-kill studies with micafungin and voriconazole against Candida glabrata intracellularly in human monocyte-derived macrophages and extracellularly in broth.米卡芬净和伏立康唑对人单核细胞衍生巨噬细胞内和肉汤外的光滑念珠菌的时间杀伤研究。
Diagn Microbiol Infect Dis. 2011 Aug;70(4):468-74. doi: 10.1016/j.diagmicrobio.2011.04.008.
10
In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.体外杀菌活性的棘白菌素类药物对念珠菌属 metapsilosis 、 C. orthopsilosis 和 C. parapsilosis 通过时间杀死研究评估。
Antimicrob Agents Chemother. 2010 May;54(5):2194-7. doi: 10.1128/AAC.01538-09. Epub 2010 Feb 9.
Zotero 插件