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Rev Iberoam Micol. 2014 Jan-Mar;31(1):42-8. doi: 10.1016/j.riam.2013.10.001. Epub 2013 Nov 19.
2
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?使用CLSI和EUCAST方法检测念珠菌属对卡泊芬净的最低抑菌浓度（MIC）的实验室间变异性：临床实验室是否应该检测这种药物？
Antimicrob Agents Chemother. 2013 Dec;57(12):5836-42. doi: 10.1128/AAC.01519-13. Epub 2013 Sep 9.
3
Inhibitory and fungicidal effects of antifungal drugs against Aspergillus species in the presence of serum.抗真菌药物在血清存在下对曲霉菌属的抑制和杀菌作用。
Antimicrob Agents Chemother. 2013 Apr;57(4):1625-31. doi: 10.1128/AAC.01573-12. Epub 2013 Jan 14.
4
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J Antimicrob Chemother. 2013 Apr;68(4):864-8. doi: 10.1093/jac/dks489. Epub 2012 Dec 9.
5
[First case report of catheter-related fungemia by Candida nivariensis in the Iberian Peninsula].[伊比利亚半岛首例光滑念珠菌引起的导管相关真菌血症病例报告]
Rev Iberoam Micol. 2013 Jan 3;30(1):69-71. doi: 10.1016/j.riam.2012.09.001. Epub 2012 Sep 14.
6
Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey.一项西班牙多中心前瞻性调查：血流真菌感染的流行病学、菌种分布和体外抗真菌药敏性。
J Antimicrob Chemother. 2012 May;67(5):1181-7. doi: 10.1093/jac/dks019. Epub 2012 Feb 20.
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Post-antifungal effects and time-kill studies of anidulafungin, caspofungin, and micafungin against Candida glabrata and Candida parapsilosis.棘白菌素类药物（安尼卡宾、卡泊芬净和米卡芬净）对光滑念珠菌和近平滑念珠菌的抗真菌后效应和时间杀菌研究。
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Prevalence and antifungal susceptibility patterns of new cryptic species inside the species complexes Candida parapsilosis and Candida glabrata among blood isolates from a Spanish tertiary hospital.在西班牙一家三级医院的血液分离株中，副念珠菌和光滑念珠菌种内复合群中新隐球菌种的流行情况及抗真菌药敏模式。
J Antimicrob Chemother. 2011 Oct;66(10):2315-22. doi: 10.1093/jac/dkr298. Epub 2011 Jul 26.
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Time-kill studies with micafungin and voriconazole against Candida glabrata intracellularly in human monocyte-derived macrophages and extracellularly in broth.米卡芬净和伏立康唑对人单核细胞衍生巨噬细胞内和肉汤外的光滑念珠菌的时间杀伤研究。
Diagn Microbiol Infect Dis. 2011 Aug;70(4):468-74. doi: 10.1016/j.diagmicrobio.2011.04.008.
10
In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.体外杀菌活性的棘白菌素类药物对念珠菌属 metapsilosis 、 C. orthopsilosis 和 C. parapsilosis 通过时间杀死研究评估。
Antimicrob Agents Chemother. 2010 May;54(5):2194-7. doi: 10.1128/AAC.01538-09. Epub 2010 Feb 9.

通过时间-杀菌研究评估阿尼芬净、卡泊芬净和米卡芬净对光滑念珠菌、布拉氏念珠菌和尼瓦念珠菌的体外杀菌活性。

In vitro fungicidal activities of anidulafungin, caspofungin, and micafungin against Candida glabrata, Candida bracarensis, and Candida nivariensis evaluated by time-kill studies.

作者信息

Gil-Alonso Sandra, Jauregizar Nerea, Cantón Emilia, Eraso Elena, Quindós Guillermo

机构信息

Departamento de Inmunología, Microbiología y Parasitología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain Departamento de Farmacología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.

Departamento de Farmacología, Unidad de Formación e Investigación Multidisciplinar Microbios y Salud (UFI 11/25), Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Bilbao, Spain.

出版信息

Antimicrob Agents Chemother. 2015;59(6):3615-8. doi: 10.1128/AAC.04474-14. Epub 2015 Mar 23.

DOI:10.1128/AAC.04474-14
PMID:25801575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432200/
Abstract

Anidulafungin, caspofungin, and micafungin killing activities against Candida glabrata, Candida bracarensis, and Candida nivariensis were evaluated by the time-kill methodology. The concentrations assayed were 0.06, 0.125, and 0.5 μg/ml, which are achieved in serum. Anidulafungin and micafungin required between 13 and 26 h to reach the fungicidal endpoint (99.9% killing) against C. glabrata and C. bracarensis. All echinocandins were less active against C. nivariensis.

摘要

采用时间杀菌法评估了阿尼芬净、卡泊芬净和米卡芬净对光滑念珠菌、布拉氏念珠菌和 nivariensis 念珠菌的杀菌活性。所测定的浓度为 0.06、0.125 和 0.5 μg/ml，这些浓度可在血清中达到。阿尼芬净和米卡芬净对光滑念珠菌和布拉氏念珠菌达到杀菌终点（杀灭 99.9%）需要 13 至 26 小时。所有棘白菌素对 nivariensis 念珠菌的活性较低。