Morrell Matthew R, Pilewski Joseph M
Lung Transplant Program, University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA.
Lung Transplant Program, University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA; Adult Cystic Fibrosis Program, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh Medical Center, NW628 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA.
Clin Chest Med. 2016 Mar;37(1):127-38. doi: 10.1016/j.ccm.2015.11.008.
Lung transplantation is a viable option for many patients with cystic fibrosis (CF) and end-stage lung disease. Criteria for transplant in patients with CF vary widely among transplant centers in terms of acceptable comorbidities; referral to multiple centers may be necessary to maximize patient opportunity for this potentially life-prolonging intervention. Early referral is critical to patient education and modification of risk factors associated with worse outcomes. If transplant evaluation has been completed, patients with CF and respiratory failure requiring mechanical ventilation and extracorporeal membrane oxygenation may remain viable candidates for transplant with outcomes comparable to other individuals with CF.
肺移植对于许多患有囊性纤维化（CF）和终末期肺病的患者来说是一种可行的选择。在可接受的合并症方面，CF患者的移植标准在不同移植中心差异很大；可能有必要转诊至多个中心，以最大程度地为患者提供这种可能延长生命的干预措施的机会。早期转诊对于患者教育以及改变与较差预后相关的风险因素至关重要。如果已经完成移植评估，患有CF且呼吸衰竭需要机械通气和体外膜肺氧合的患者可能仍是可行的移植候选人，其预后与其他CF患者相当。
