The Ohio State University, Columbus, OH, USA.
J Cyst Fibros. 2012 Jan;11(1):40-5. doi: 10.1016/j.jcf.2011.07.009. Epub 2011 Oct 26.
Venovenous extracorporeal membrane oxygenation (VV ECMO) is a therapeutic option to bridge patients with advanced lung disease to lung transplantation. The use of VV ECMO avoids the use of mechanical ventilation while allowing patients to participate in physical therapy and to eat normally while receiving respiratory support. We describe the successful use of ambulatory single-venous VV ECMO as a bridge to bilateral lung transplantation in 4 patients with end-stage lung disease due to cystic fibrosis who developed acute hypercapnic respiratory failure. The use of ambulatory single-venous VV ECMO was safe and effective in this small cohort of CF patients. Based on our experiences, our belief is that a key step in the treatment course was early application of VV ECMO soon after development of acute respiratory failure requiring mechanical ventilation.
静脉-静脉体外膜肺氧合（VV ECMO）是一种治疗选择，可以将患有晚期肺病的患者桥接到肺移植。使用 VV ECMO 可以避免使用机械通气，同时允许患者在接受呼吸支持的同时进行物理治疗和正常进食。我们描述了 4 例因囊性纤维化而患有终末期肺病的患者，他们因急性高碳酸血症呼吸衰竭而使用门诊单静脉 VV ECMO 成功桥接到双侧肺移植。在这组小的 CF 患者中，使用门诊单静脉 VV ECMO 是安全有效的。根据我们的经验，我们认为治疗过程中的一个关键步骤是在需要机械通气的急性呼吸衰竭发生后尽早应用 VV ECMO。
