Serrano Ângela, Zürcher Stefan, Tosatti Samuele, Spencer Nicholas D
SuSoS AG, Lagerstrasse 14, CH-8600, Dübendorf, Switzerland.
Laboratory for Surface Science and Technology, Department of Materials, ETH Zürich, Vladimir-Prelog-Weg 5, CH-8093, Zürich, Switzerland.
Macromol Rapid Commun. 2016 Apr;37(7):622-9. doi: 10.1002/marc.201500683. Epub 2016 Feb 9.
Surface-active polymers that display nonfouling properties and carry binding groups that can adsorb onto different substrates are highly desirable. We present a postmodification protocol of an active-ester-containing polymer that allows the creation of such a versatile platform. Poly(pentafluorophenyl acrylate) has been postmodified with a fixed grafting ratio of a nonfouling function (mPEG) and various combinations of functional groups, such as amine, silane and catechol, which can provide strong affinity to two model substrates: SiO2 and TiO2 . Adsorption, stability and resistance to nonspecific protein adsorption of the polymer films were studied. A polymer was obtained that maintained its surface functionality under a variety of harsh conditions. EG surface-density calculations show that this strategy generates a denser packing when both negatively and positively charged groups are present within the backbone, and readily allows the fabrication of a broad combinatorial matrix.
具有抗污性能并带有可吸附到不同基质上的结合基团的表面活性聚合物是非常理想的。我们提出了一种含活性酯聚合物的后修饰方案，该方案能够创建这样一个多功能平台。聚（五氟苯基丙烯酸酯）已通过具有固定接枝率的抗污功能（甲氧基聚乙二醇）以及各种官能团组合（如胺、硅烷和儿茶酚）进行后修饰，这些官能团可对两种模型基质（二氧化硅和二氧化钛）提供强亲和力。研究了聚合物薄膜的吸附、稳定性以及对非特异性蛋白质吸附的抗性。获得了一种在各种苛刻条件下仍能保持其表面功能的聚合物。乙二醇表面密度计算表明，当主链中同时存在带负电和带正电的基团时，该策略会产生更密集的堆积，并且易于制备广泛的组合基质。
