Teratani Takumi, Kobayashi Eiji
Division of Development of Advanced Therapy, Center for Development of Advanced Medical Technology, Jichi Medical University , Shimotsukeshi, Tochigi , Japan.
Cell Med. 2013 Aug 29;5(2-3):45-51. doi: 10.3727/215517913X666549. eCollection 2013 Nov 10.
Research in the life sciences has been greatly advanced by the ability to directly visualize cells, tissues, and organs. Preclinical studies often involve many small and large animal experiments and, frequently, cell and organ transplantations. The rat is an excellent animal model for the development of transplantation and surgical techniques because of its small size and ability to breed in small spaces. Ten years ago, we established color-imaging transgenic rats and methods for the direct visualization of their tissues. Since then, our transgenic rats have been used throughout the various fields that are concerned with cell transplantation therapy. In this minireview, we summarize results from some of the groups that have used our transgenic rats at the bench level and in cell transplantation research.
能够直接观察细胞、组织和器官极大地推动了生命科学的研究。临床前研究通常涉及许多大小动物实验，并且经常进行细胞和器官移植。大鼠因其体型小且能在小空间内繁殖，是移植和外科技术开发的优秀动物模型。十年前，我们建立了彩色成像转基因大鼠及其组织直接可视化方法。从那时起，我们的转基因大鼠已被应用于与细胞移植治疗相关的各个领域。在本综述中，我们总结了一些在实验室水平和细胞移植研究中使用我们转基因大鼠的研究小组的结果。
