用于细胞和组织移植转化研究的体内生物成像大鼠
In Vivo Bioimaging Rats for Translational Research in Cell and Tissue Transplantation.
作者信息
Teratani Takumi, Kobayashi Eiji
机构信息
Division of Development of Advanced Therapy, Center for Development of Advanced Medical Technology, Jichi Medical University , Shimotsuke-shi, Tochigi , Japan.
出版信息
Cell Med. 2012 May 15;3(1-3):3-11. doi: 10.3727/215517912X639342. eCollection 2012 Jan.
Abstract
The rat is an excellent cell transplantation model. In accordance with the innovative development of in vivo bioimaging technology, over the last decade we have been developing an engineered rat system based on transgenic technology and have been demonstrating the usefulness of the system with genetically encoded imaging probes such as fluorescent and luminescent proteins. In cooperation with the Japan Society for Organ Preservation and Medical Biology (President: Professor T. Asano), we have also been using luciferase-Tg rats for research into organ preservation and cell transplantation. In this minireview, we introduce the results obtained recently by using these powerful experimental tools during international collaboration in cell transplantation research.
摘要
大鼠是一种优秀的细胞移植模型。随着体内生物成像技术的创新发展，在过去十年中，我们一直在基于转基因技术开发一种工程大鼠系统，并一直在用荧光蛋白和发光蛋白等基因编码成像探针证明该系统的实用性。我们还与日本器官保存与医学生物学协会（会长：浅野哲教授）合作，将荧光素酶转基因大鼠用于器官保存和细胞移植研究。在这篇小型综述中，我们介绍了在细胞移植研究的国际合作中使用这些强大实验工具最近获得的结果。
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本文引用的文献
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Cell Transplant. 2012;21(9):1837-51. doi: 10.3727/096368911X627426. Epub 2012 Mar 8.
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Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model.骨髓间充质干细胞改善大鼠肝缺血再灌注损伤。
PLoS One. 2011 Apr 29;6(4):e19195. doi: 10.1371/journal.pone.0019195.
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Luminescence technology in preservation and transplantation for rat islet.大鼠胰岛保存与移植中的荧光技术。
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4
Luminescence imaging of regenerating free bone graft in rats.大鼠游离骨移植再生的荧光成像研究。
Plast Reconstr Surg. 2011 Jan;127(1):78-87. doi: 10.1097/PRS.0b013e3181f959b2.
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Equivalent neurogenic potential of wild-type and GFP-labeled fetal-derived neural progenitor cells before and after transplantation into the rodent hippocampus.移植到啮齿动物海马体前后，野生型和 GFP 标记的胎鼠源性神经祖细胞具有等效的神经发生潜能。
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Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect.关节内注射的滑膜干细胞可直接分化为半月板细胞，并促进半月板再生，在大鼠大面积半月板缺损模型中不会迁移至远处器官。
Stem Cells. 2009 Apr;27(4):878-87. doi: 10.1634/stemcells.2008-0616.
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In vivo bioimaging using photogenic rats: fate of injected bone marrow-derived mesenchymal stromal cells.使用发光大鼠进行的体内生物成像：注射的骨髓间充质基质细胞的命运
J Autoimmun. 2008 May;30(3):163-71. doi: 10.1016/j.jaut.2007.12.007. Epub 2008 Jan 25.
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In vivo visualization and portally repeated transplantation of bone marrow cells in rats with liver damage.肝损伤大鼠骨髓细胞的体内可视化及门静脉重复移植
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