Schindler Tim, Gilbert Yasmin, Wu Linda, Oei Ju Lee, Welsh Alec
Departments of Newborn Care (T.S., J.L.O.) and Maternal-Fetal Medicine (A.W.), Royal Hospital for Women, Randwick, New South Wales, Australia; and Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia (T.S., Y.G., L.W., J.L.O., A.W.)
Departments of Newborn Care (T.S., J.L.O.) and Maternal-Fetal Medicine (A.W.), Royal Hospital for Women, Randwick, New South Wales, Australia; and Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia (T.S., Y.G., L.W., J.L.O., A.W.).
J Ultrasound Med. 2016 Mar;35(3):505-10. doi: 10.7863/ultra.15.05022. Epub 2016 Feb 9.
Changes in tissue perfusion can be critically important in the vulnerable neonate, but they are very difficult to assess at the bedside. Spatiotemporal image correlation (STIC) sonography is an exciting concept that allows assessment of blood flow by rearranging and merging multiple 2-dimensional color images to create serial 3-dimensional images showing regional blood flow throughout the cardiac cycle. Variations in tissue blood flow may reflect tissue impedance and perfusion. The aim of this study was to demonstrate that it is possible to use STIC images to evaluate tissue impedance in the neonatal brain.
Spatiotemporal image correlation data sets were acquired by cranial sonography in 19 neonates. Offline data analysis was performed by using virtual organ computer-aided analysis. With the use of STIC images from different phases of the cardiac cycle, impedance indices were calculated, based on maximum (systolic), minimum (diastolic), and mean virtual organ computer-aided analysis values, in the same way that resistive indices are calculated in 2-dimensional sonography.
Volumetric indices for tissue impedance were obtained for all neonates. Intraclass correlation coefficients (95% confidence intervals) for volumetric impedance indices were as follows: systolic/diastolic ratio, 0.793 (0.615-0.906); pulsatility index, 0.790 (0.609-0.905); and resistive index, 0.783 (0.598-0.901). Interclass correlation coefficients for image processing and analysis were as follows: systolic/diastolic ratio, 0.868 (0.692-0.947); pulsatility index, 0.904 (0.772-0.962); and resistive index, 0.914 (0.794-0.966).
This study shows that STIC data sets can be used to calculate volumetric impedance indices in the neonatal brain. Preliminary assessment shows that this technique appears reliable and allows evaluation of regional tissue impedance in the neonate.
组织灌注的变化对于脆弱的新生儿可能至关重要，但在床边很难评估。时空图像相关（STIC）超声检查是一个令人兴奋的概念，它通过重新排列和合并多个二维彩色图像来评估血流，以创建显示整个心动周期区域血流的连续三维图像。组织血流的变化可能反映组织阻抗和灌注。本研究的目的是证明可以使用STIC图像评估新生儿脑内的组织阻抗。
通过头颅超声检查获取19例新生儿的时空图像相关数据集。使用虚拟器官计算机辅助分析进行离线数据分析。利用心动周期不同阶段的STIC图像，基于最大（收缩期）、最小（舒张期）和平均虚拟器官计算机辅助分析值计算阻抗指数，计算方式与二维超声检查中计算阻力指数相同。
所有新生儿均获得了组织阻抗体积指数。体积阻抗指数的组内相关系数（95%置信区间）如下：收缩期/舒张期比值为0.793（0.615 - 0.
