介孔硅和铝硅酸盐载体用于四环素类药物输送系统。
Mesostructured silica and aluminosilicate carriers for oxytetracycline delivery systems.
机构信息
University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
University "Politehnica" of Bucharest, Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Polizu street no. 1-7, Bucharest 011061, Romania.
出版信息
Int J Pharm. 2016 Aug 30;510(2):524-31. doi: 10.1016/j.ijpharm.2016.02.009. Epub 2016 Feb 6.
Oxytetracycline delivery systems containing various MCM-type silica and aluminosilicate with different antibiotic content were developed in order to establish the influence of the support structural and textural properties and aluminum content on the drug release profile. The antibiotic molecules were loaded into the support mesochannels by incipient wetness impregnation method using a drug concentrated aqueous solution. The carriers and drug-loaded materials were investigated by small- and wide-angle XRD, FTIR spectroscopy, TEM and N2 adsorption-desorption isotherms. Faster release kinetics of oxytetracycline from uncalcined silica and aluminosilicate supports was observed, whereas higher drug content led to lower delivery rate. The presence of aluminum into the silica network also slowed down the release rate. The antimicrobial assays performed on Staphylococcus aureus clinical isolates showed that the oxytetracycline-loaded materials containing MCM-41-type mesoporous silica or aluminosilicate carriers inhibited the bacterial development.
为了研究载体的结构和织构性质以及铝含量对药物释放特性的影响，制备了含有不同载药量的各种 MCM 型硅基和硅铝酸盐的土霉素给药系统。通过使用药物浓水溶液的初始湿法浸渍法，将抗生素分子载入载体的介孔中。采用小角和广角 XRD、FTIR 光谱、TEM 和 N2 吸附-脱附等温线对载体和载药材料进行了研究。结果表明，未煅烧的硅基和硅铝酸盐载体中，土霉素的释放动力学更快，而较高的药物含量则导致较低的释放速率。此外，硅网络中铝的存在也会降低释放速率。对金黄色葡萄球菌临床分离株进行的抗菌试验表明，载有 MCM-41 型介孔硅或硅铝酸盐载体的土霉素载药材料抑制了细菌的生长。
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