Wang Yi, Zhu Jun, Han Jie, Guo Rong
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, PR China.
J Nanosci Nanotechnol. 2009 Nov;9(11):6700-9. doi: 10.1166/jnn.2009.1351.
A series of mesostructured Mn-MCM-41 composites were synthesized via a co-assembly route with tetraethylorthosilicate (TEOS) and manganese sulfate (MnSO4) as silica and manganese sources, respectively. And a model drug of cephanone was introduced via physical adsorption process into the channels of mesoporous silica, which could be used as the Mn-MCM-41 type mesoporous silica-based drug controlled-release delivery system. XRD, TEM, FT-IR, EDS and N2 adsorption-desorption were used to characterize the structural and textural properties of Mn-MCM-41 composites. The investigations showed that the addition of a small amount of manganese species was favorable for the long-range ordered structure of the mesoporous composites, whereas the ordered mesostructure was partially or completely distorted when the loaded manganese increased. The characterizations of cephanone loaded Mn-MCM-41 and in vitro release studies showed that the in vitro releases of cephanone in the ordered mesoporous materials follow an anomalous non-Fick's transport, and the impregnated manganese species had great influences on the release rate of cephanone from mesopores.
通过共组装路线，分别以正硅酸乙酯（TEOS）和硫酸锰（MnSO4）作为硅源和锰源，合成了一系列介孔结构的Mn-MCM-41复合材料。通过物理吸附过程将头孢酮模型药物引入介孔二氧化硅的孔道中，其可作为基于Mn-MCM-41型介孔二氧化硅的药物控释递送系统。采用XRD、TEM、FT-IR、EDS和N2吸附-脱附对Mn-MCM-41复合材料的结构和织构性质进行了表征。研究表明，少量锰物种的加入有利于介孔复合材料的长程有序结构，而当负载的锰增加时，有序介孔结构会部分或完全扭曲。负载头孢酮的Mn-MCM-41的表征及体外释放研究表明，头孢酮在有序介孔材料中的体外释放遵循非菲克反常传输，且浸渍的锰物种对头孢酮从介孔中的释放速率有很大影响。
