羊毛甾醇对人白内障晶状体核的影响。
Effect of lanosterol on human cataract nucleus.
作者信息
Shanmugam P Mahesh, Barigali Aditya, Kadaskar Jayant, Borgohain Sandip, Mishra Divaynsh Kailash Chandra, Ramanjulu Rajesh, Minija C K
机构信息
Department of Vitreoretinal Services and Ocular Oncology, Sankara Eye Hospital, Kundalahalli Gate, Bengaluru, Karnataka, India.
出版信息
Indian J Ophthalmol. 2015 Dec;63(12):888-90. doi: 10.4103/0301-4738.176040.
AIM
To study the effect of lanosterol on age-related cataractous human lens nuclei.
MATERIALS AND METHODS
Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity.
RESULTS
Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days.
CONCLUSION
Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.
目的
研究羊毛甾醇对年龄相关性白内障人晶状体核的影响。
材料与方法
获取在手法小切口白内障手术中摘除的40个年龄相关性白内障核，随机将其浸入25 mM羊毛甾醇溶液或对照溶液中，并在室温下保存6天。两名不知情的观察者对浸泡前后的照片进行分级，并整理晶状体混浊的消退或进展情况。
结果
6天结束时，羊毛甾醇组和对照组的晶状体混浊均有进展或无变化。
结论
25 mM羊毛甾醇溶液不能逆转人年龄相关性白内障核的混浊。
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