偏头痛的血液基因表达研究：潜力与注意事项。
Blood gene expression studies in migraine: Potential and caveats.
作者信息
Gerring Zachary, Rodriguez-Acevedo Astrid J, Powell Joseph E, Griffiths Lyn R, Montgomery Grant W, Nyholt Dale R
机构信息
Statistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia The Centre for Neurogenetics and Statistical Genomics, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
出版信息
Cephalalgia. 2016 Jun;36(7):669-78. doi: 10.1177/0333102416628463. Epub 2016 Feb 9.
BACKGROUND
Global gene expression analysis may be used to obtain insights into the functional processes underlying migraine. However, there is a shortage of high-quality post-mortem brain tissue samples for genetic analysis. One approach is to use a more accessible tissue as a surrogate, such as peripheral blood.
PURPOSE
Discuss the benefits and caveats of blood genomic profiling in migraine and its potential application in the development of biomarkers of migraine susceptibility and outcome. Demonstrate the utility of blood-based expression profiles in migraine by analysing pilot Illumina HT-12 expression data from 76 (38 case, 38 control) whole-blood samples.
CONCLUSION
Current evidence suggests peripheral blood is a biologically valid substrate for genetic studies of migraine, and may be used to identify biomarkers and therapeutic pathways. Pilot blood gene expression data confirm that expression profiles significantly differ between migraine case and non-migraine control individuals.
背景
全球基因表达分析可用于深入了解偏头痛潜在的功能过程。然而，用于基因分析的高质量尸检脑组织样本短缺。一种方法是使用更容易获取的组织作为替代物，比如外周血。
目的
讨论偏头痛血液基因组分析的益处与注意事项，及其在偏头痛易感性和预后生物标志物开发中的潜在应用。通过分析来自76份（38例、38例对照）全血样本的Illumina HT-12先导表达数据，证明基于血液的表达谱在偏头痛中的实用性。
结论
当前证据表明外周血是偏头痛基因研究的生物学有效底物，可用于识别生物标志物和治疗途径。先导血液基因表达数据证实，偏头痛病例与非偏头痛对照个体之间的表达谱存在显著差异。
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