Wollina U, Hipler C, Knopf B, Koch H J
Universitäts-Hautklinik Jena.
Z Hautkr. 1989 Oct 15;64(10):925-7.
Frozen sections from psoriatic lesions were investigated regarding their reactivity with endothelial markers (UEA I, EEA I, LTA, Con A, factor VIII-related antigen). We compared the findings obtained with those of both uninvolved psoriatic skin and normal skin. Although all lectins showed altered epidermal binding in comparison to the controls, the endothelial lectin binding as well as the expression of factor VIII-related antigen were the same in both psoriatric lesions and controls. Our findings argue for (1) intact dimorphic genetic control of ABH expression in both epidermal and endothelial cells, (2) altered epidermal differentiation of lesional psoriatric skin, and (3) secondary vascular alterations.
对银屑病皮损的冰冻切片进行研究，观察其与内皮标记物（荆豆凝集素I、早期内皮细胞标记物I、荆豆凝集素A、刀豆球蛋白A、VIII因子相关抗原）的反应性。我们将所得结果与未受累的银屑病皮肤及正常皮肤的结果进行了比较。尽管与对照组相比，所有凝集素均显示出表皮结合的改变，但银屑病皮损和对照组中内皮凝集素结合以及VIII因子相关抗原的表达是相同的。我们的研究结果支持以下观点：（1）表皮和内皮细胞中ABH表达存在完整的双态遗传控制；（2）银屑病皮损皮肤的表皮分化改变；（3）继发性血管改变。
