Kim Jungkyu, Stockton Amanda M, Jensen Erik C, Mathies Richard A
Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, USA.
Department of Chemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Lab Chip. 2016 Mar 7;16(5):812-9. doi: 10.1039/c5lc01397f.
Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices--a new device is needed to implement each new chemical or biochemical assay. PMPs are analogous to digital electronic processors--all that is needed to implement a new assay is a change in the order of operations conducted by the device. In this review, we introduce PMPs based on normally-closed microvalves. We discuss recent applications of PMPs in diverse fields including genetic analysis, antibody-based biomarker analysis, and chemical analysis in planetary exploration. Prospects, challenges, and future concepts for this emerging technology will also be presented.
可编程微流控平台（PMPs）正在推动微流控技术在化学和生化分析应用方面取得重大进展。传统微流控设备类似于特定应用设备——实施每种新的化学或生化检测都需要一种新设备。PMPs类似于数字电子处理器——实施新检测所需的一切只是改变设备执行操作的顺序。在本综述中，我们介绍基于常闭微阀的PMPs。我们讨论了PMPs在包括基因分析、基于抗体的生物标志物分析以及行星探索中的化学分析等不同领域的最新应用。还将介绍这项新兴技术的前景、挑战和未来概念。
