食品、药物和化妆品染料：与脂溶性相关的生物学效应。
Food, drug, and cosmetic dyes: biological effects related to lipid solubility.
作者信息
Levitan H
出版信息
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2914-8. doi: 10.1073/pnas.74.7.2914.
Abstract
Food, drug, and cosmetic dyes of the xanthane type (analogs of fluorescein) were applied to isolated molluscan ganglia and changes in the electrophysiological properties of identified neurons were monitored. The synthetic coloring agents increased the resting membrane potential and conductance of the neurons in a dose-dependent manner by increasing the potassium permeability of the membrane relative to that of other ions. The relative activity of these anionic dyes was highly correlated with their lipid solubility. The structure-activity study of the effects of the dyes on molluscan neurophysiology provides a basis for estimating the toxicity and brain uptake of the dyes in vertebrates, and predicting their effects on metabolism and blood clotting.
摘要
将黄原烷类（荧光素类似物）的食品、药物和化妆品染料应用于分离出的软体动物神经节，并监测已识别神经元电生理特性的变化。这些合成色素通过增加膜对钾离子相对于其他离子的通透性，以剂量依赖的方式提高了神经元的静息膜电位和电导。这些阴离子染料的相对活性与其脂溶性高度相关。染料对软体动物神经生理学影响的构效关系研究为评估染料在脊椎动物中的毒性和脑摄取量，以及预测它们对代谢和血液凝固的影响提供了依据。
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