人类癌症中顺铂耐药的分子基础：模型系统与患者
Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.
作者信息
Scanlon K J, Kashani-Sabet M, Miyachi H, Sowers L C, Rossi J
机构信息
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010.
出版信息
Anticancer Res. 1989 Sep-Oct;9(5):1301-12.
In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors will be entertained.
在本综述中，将总结顺铂耐药性。我们将讨论卵巢癌、结肠癌和乳腺癌患者组织中潜在耐药机制的特征。其次，将讨论一种新的分子生物学检测方法，该方法可检测顺铂耐药细胞中基因表达的变化。最后，基于顺铂耐药肿瘤的生化和分子特性，将探讨在人类肿瘤中利用或规避顺铂耐药性的新策略。
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