Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
Department of Chemistry, Indian Institute of Technology , Kanpur 208016, India.
J Am Chem Soc. 2016 Mar 2;138(8):2823-8. doi: 10.1021/jacs.5b13533. Epub 2016 Feb 19.
Covalent organic nanosheets (CONs) have emerged as functional two-dimensional materials for versatile applications. Although π-π stacking between layers, hydrolytic instability, possible restacking prevents their exfoliation on to few thin layered CONs from crystalline porous polymers. We anticipated rational designing of a structure by intrinsic ionic linker could be the solution to produce self-exfoliated CONs without external stimuli. In an attempt to address this issue, we have synthesized three self-exfoliated guanidinium halide based ionic covalent organic nanosheets (iCONs) with antimicrobial property. Self-exfoliation phenomenon has been supported by molecular dynamics (MD) simulation as well. Intrinsic ionic guanidinium unit plays the pivotal role for both self-exfoliation and antibacterial property against both Gram-positive and Gram-negative bacteria. Using such iCONs, we have devised a mixed matrix membrane which could be useful for antimicrobial coatings with plausible medical benefits.
共价有机纳米片（CONs）作为多功能二维材料已经崭露头角。尽管层间的π-π堆积、水解不稳定性以及可能的再堆积阻止了它们从结晶多孔聚合物中剥离成少数几层薄的 CONs。我们预计，通过内在离子键的合理设计可能是制备无需外部刺激即可自剥离 CONs 的解决方案。为了解决这个问题，我们已经合成了三种具有抗菌性能的自剥离卤化胍基离子共价有机纳米片（iCONs）。自剥离现象也得到了分子动力学（MD）模拟的支持。内在的离子胍基单元对于自剥离和对革兰氏阳性菌和革兰氏阴性菌的抗菌性能都起着关键作用。使用这种 iCONs，我们设计了一种混合基质膜，它可以用于具有潜在医学益处的抗菌涂层。
