Themphachanal Monchanok, Kongpheng Suttiporn, Rattanachuay Pattamarat, Khianngam Saowapar, Singkhamanan Kamonnut, Sukhumungoon Pharanai
Southeast Asian J Trop Med Public Health. 2015 Nov;46(6):1021-30.
Among uropathogens, uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infection (UTI) worldwide, but clinical aspects due to this bacterial species is not fully understood in southern Thailand. Two hundred fifty-four UPEC isolates from patients admitted to Maharaj Nakhon Si Thammarat Hospital, southern Thailand were examined for crucial virulence genes, showing that 33.5% contained at least one of the virulence, genes tested. Genes encoding P fimbria, cytotoxic necrotizing factor-1 and α-hemolysin constituted the majority (15.8%) carried by UPEC isolates. Phylogenetic group classification revealed that 57.5% of UPEC belonged to group D. Antimicrobial susceptibility tests showed that 70.5% and 65.1% of the isolates were resistant to ciprofloxacin and norfloxacin, respectively. Moreover, 50.0% of UPEC were capable of producing extended spectrum beta-lactamases. These findings should be of benefit for more appropriate treatment of UTI patients in this region of Thailand. Keywords: uropathogenic Escherichia coli, antibiotics resistance, cnfl, hlyA, pap, Thailand
在尿路病原体中，尿路致病性大肠杆菌（UPEC）是全球尿路感染（UTI）最常见的病因，但泰国南部对这种细菌的临床情况尚未完全了解。对泰国南部那空是贪玛叻玛哈叻医院收治患者的254株UPEC分离株进行关键毒力基因检测，结果显示33.5%的分离株至少含有一种检测的毒力基因。编码P菌毛、细胞毒性坏死因子-1和α-溶血素的基因在UPEC分离株携带的基因中占大多数（15.8%）。系统发育组分类显示57.5%的UPEC属于D组。药敏试验表明，70.5%和65.1%的分离株分别对环丙沙星和诺氟沙星耐药。此外，50.0%的UPEC能够产生超广谱β-内酰胺酶。这些发现应有助于泰国该地区更恰当地治疗UTI患者。关键词：尿路致病性大肠杆菌、抗生素耐药性、cnfl、hlyA、pap、泰国
