Prodrugs.
作者信息
Waller D G, George C F
机构信息
Clinical Pharmacology Group, Southampton General Hospital.
出版信息
Br J Clin Pharmacol. 1989 Nov;28(5):497-507. doi: 10.1111/j.1365-2125.1989.tb03535.x.
Abstract
摘要
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Prodrugs.前体药物
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本文引用的文献
1
Chemical aspects of selective toxicity.选择性毒性的化学方面。
Nature. 1958 Aug 16;182(4633):421-2. doi: 10.1038/182421a0.
2
A metabolite of sulphinpyrazone that is largely responsible for the effect of the drug on the platelet prostaglandin pathway.磺吡酮的一种代谢产物，它在很大程度上决定了该药物对血小板前列腺素途径的作用。
Biochem Soc Trans. 1980 Dec;8(6):727-8. doi: 10.1042/bst0080727.
3
Systemic absorption of topical ocularly applied epinephrine and dipivefrin.局部眼部应用肾上腺素和地匹福林的全身吸收。
Arch Ophthalmol. 1980 Feb;98(2):350-3. doi: 10.1001/archopht.1980.01020030346024.
4
Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate.
Clin Pharmacol Ther. 1981 Sep;30(3):368-72. doi: 10.1038/clpt.1981.174.
5
Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy.酰基酶介导的纤维蛋白溶解：溶栓治疗的新方法。
Nature. 1981 Apr 9;290(5806):505-8. doi: 10.1038/290505a0.
6
The role of the gut flora in the reduction of sulphinpyrazone in the rat.肠道菌群在大鼠体内对磺吡酮的还原作用。
Biochem Pharmacol. 1982 Aug 15;31(16):2649-56. doi: 10.1016/0006-2952(82)90713-4.
7
UK general practitioners experience of fenbufen in elderly patients.英国全科医生对老年患者使用芬布芬的经验。
Eur J Rheumatol Inflamm. 1982;5(3):326-31.
8
Sulindac: therapeutic implications of the prodrug/pharmacophore equilibrium.舒林酸：前药/药效基团平衡的治疗意义。
Drug Metab Rev. 1981;12(2):325-37. doi: 10.3109/03602538108994035.
9
Are all aspirins really alike? A comparison of gastric ulcerogenicity with bio-efficacy in rats.所有阿司匹林真的都一样吗？大鼠胃溃疡形成性与生物有效性的比较。
Pharmacol Res Commun. 1980 Jan;12(1):85-95. doi: 10.1016/s0031-6989(80)80066-x.
10
Gamma-aminobutyric acid esters. 1. Synthesis, brain uptake, and pharmacological studies of aliphatic and steroid esters of gamma-aminobutyric acid.
J Med Chem. 1984 May;27(5):659-64. doi: 10.1021/jm00371a018.
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