Bint A J, Cefai C, McGhie D, Perera B S
Br J Clin Pract. 1989 Jan;43(1):19-23.
Cefadroxil 1 g twice daily and amoxycillin 500 mg three times a day were compared in 111 patients suffering from acute exacerbations of chronic bronchitis. Treatment was for seven days. Excellent or good clinical responses were found in 85 per cent of cases receiving cefadroxil and 81 per cent of patients taking amoxycillin. However, residual symptoms of cough and rhonchi were present to a statistically significantly greater extent in the amoxycillin group. Tolerance of both drugs was good with mild to moderate side effects reported in seven of 54 patients in the cefadroxil group and six of 56 patients taking amoxycillin. Severe nausea and vomiting in two cases in the amoxycillin group resulted in discontinuation of therapy. Microbiological examination of sputum samples showed pathogenic bacteria in 16 per cent, principally Haemophilus influenzae. Amoxycillin 500 mg tds and cefadroxil 1 g bd were equally effective in the treatment of acute exacerbations of chronic bronchitis.
对111例慢性支气管炎急性加重期患者比较了头孢羟氨苄每日2次、每次1g与阿莫西林每日3次、每次500mg的疗效。疗程为7天。接受头孢羟氨苄治疗的患者中85%以及服用阿莫西林的患者中81%获得了优秀或良好的临床反应。然而，阿莫西林组咳嗽和干啰音等残留症状在统计学上显著更严重。两种药物的耐受性均良好，头孢羟氨苄组54例患者中有7例、服用阿莫西林的56例患者中有6例报告有轻至中度副作用。阿莫西林组有2例出现严重恶心和呕吐，导致治疗中断。痰标本的微生物学检查显示16%有病原菌，主要是流感嗜血杆菌。阿莫西林500mg每日3次和头孢羟氨苄1g每日2次在治疗慢性支气管炎急性加重期方面同样有效。
