Hanretty K P, Primrose M H, Neilson J P, Whittle M J
Department of Midwifery, University of Glasgow, Queen Mother's Hospital, Yorkhill.
Br J Obstet Gynaecol. 1989 Oct;96(10):1163-7. doi: 10.1111/j.1471-0528.1989.tb03191.x.
Doppler waveforms from the uteroplacental and umbilical arteries were studied in 543 unselected women attending an antenatal clinic. Overall, 357 women were studied at 26-30 weeks and 395 at 34-36 weeks; 209 were studied at both gestation periods. Results were not made available to clinicians. There was no difference in outcome of pregnancies between those with normal and abnormal uteroplacental waveforms, but birthweights were significantly lower in those with an abnormal umbilical artery waveform at either gestation. There were no other statistically significant differences between groups. Although the power of the study to detect differences in outcome in this sample size is limited, our findings do not support the introduction of this new technique into clinical practice before sufficiently large randomized controlled trials have shown some benefit.
对543名未经过挑选、前往产前诊所就诊的女性进行了子宫胎盘动脉和脐动脉的多普勒波形研究。总体而言，在孕26 - 30周时对357名女性进行了研究，在孕34 - 36周时对395名女性进行了研究；209名女性在两个孕期阶段均接受了研究。研究结果未提供给临床医生。子宫胎盘波形正常和异常的孕妇，其妊娠结局并无差异，但在任何一个孕期阶段，脐动脉波形异常的孕妇所产婴儿出生体重显著较低。组间无其他具有统计学意义的差异。尽管该研究在这个样本量下检测结局差异的效能有限，但在足够大规模的随机对照试验显示出益处之前，我们的研究结果不支持将这项新技术引入临床实践。
