与药物流产同一天使用的孕激素类避孕药。
Progestin-based contraceptive on the same day as medical abortion.
作者信息
Park Jeanna, Robinson Nuriya, Wessels Ursula, Turner James, Geller Stacie
机构信息
Department of Obstetrics and Gynecology, University of Illinois, Chicago, USA.
Department of Obstetrics and Gynecology, University of Illinois, Chicago, USA.
出版信息
Int J Gynaecol Obstet. 2016 May;133(2):217-20. doi: 10.1016/j.ijgo.2015.08.025. Epub 2016 Jan 6.
OBJECTIVE
To determine the success rate of medical abortion when a progestin-based contraceptive-either an etonogestrel implant or depot medroxyprogesterone acetate (DMPA) injection-is given on the same day as mifepristone for medical abortion.
METHODS
In a retrospective chart review, data were assessed for women aged 15-49years who underwent medical abortion (≤63days of pregnancy) at two hospitals in KwaZulu Natal, South Africa, between August 2013 and July 2014. The women were given oral mifepristone (200mg) and buccal misoprostol (800μg), and received an etonogestrel implant or DMPA injection on the same day as mifepristone. The primary outcome was the success rate of medical abortion. Comparative data were obtained through a PubMed search.
RESULTS
A total of 89 women were included. Complete termination was achieved in 87 (98%, 95% confidence interval 95%-100%) women. This success rate is similar to that reported in a previous systematic review of the rate of medical abortion success without progestin contraceptive administration (94.8%).
CONCLUSIONS
Administration of a progestin-based contraceptive such as an etonogestrel implant or DMPA injection on the same day as mifepristone for medical abortion did not alter the success rates.
目的
确定在米非司酮用于药物流产当天给予基于孕激素的避孕药（依托孕烯植入剂或醋酸甲羟孕酮长效注射剂）时药物流产的成功率。
方法
在一项回顾性病历审查中，对2013年8月至2014年7月期间在南非夸祖鲁 - 纳塔尔省两家医院接受药物流产（妊娠≤63天）的15 - 49岁女性的数据进行评估。这些女性口服米非司酮（200mg）和阴道用米索前列醇（800μg），并在米非司酮给药当天接受依托孕烯植入剂或醋酸甲羟孕酮长效注射剂。主要结局是药物流产的成功率。通过PubMed搜索获得比较数据。
结果
共纳入89名女性。87名（98%，95%置信区间95% - 100%）女性实现完全流产。该成功率与先前一项未使用孕激素避孕药的药物流产成功率系统评价中报告的成功率（94.8%）相似。
结论
在米非司酮用于药物流产当天给予基于孕激素的避孕药，如依托孕烯植入剂或醋酸甲羟孕酮长效注射剂，不会改变成功率。
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