Rariy Chevon M, Rometo David, Korytkowski Mary
Division of Endocrinology, Diabetes, and Metabolism, University of Pittsburgh Medical Center (UPMC), 200 Lothrop Avenue, Pittsburgh, PA, 15225, USA.
University of Pittsburgh School of Medicine, 200 Lothrop Avenue, Pittsburgh, PA, 15225, USA.
Curr Diab Rep. 2016 Feb;16(2):19. doi: 10.1007/s11892-015-0711-5.
Obesity is a major public health problem worldwide. Obesity-related illnesses, such as coronary heart disease, type 2 diabetes, hypertension, dyslipidemia, stroke, sleep apnea, and several forms of cancer (endometrial, breast, and colon), contribute to a significant number of deaths in the USA. Bariatric surgery, including the Roux-en-Y gastric bypass (RYGB) procedure, has demonstrated significant improvements in obesity and obesity-related co-morbidities and is becoming more popular as the number of obese individuals rises. Despite the reported benefits of bariatric surgery, there are potential complications that physicians need to be aware of as the number of patients undergoing these procedures continues to increase. One challenging and potentially life-threatening complication that to date is not well understood is post-RYGB surgery hypoglycemia (PGBH). In this review, we will present the definition, historical perspective, diagnostic approach, currently available treatment options, and anecdotal assessment and treatment algorithm for this disorder.
肥胖是全球主要的公共卫生问题。与肥胖相关的疾病,如冠心病、2型糖尿病、高血压、血脂异常、中风、睡眠呼吸暂停以及几种癌症(子宫内膜癌、乳腺癌和结肠癌),在美国导致了大量死亡。减肥手术,包括 Roux-en-Y 胃旁路术(RYGB),已显示出在肥胖及肥胖相关合并症方面有显著改善,并且随着肥胖人群数量的增加而越来越受欢迎。尽管减肥手术有诸多益处,但随着接受这些手术的患者数量不断增加,医生需要了解一些潜在并发症。迄今为止,一种具有挑战性且可能危及生命的并发症——RYGB 术后低血糖症(PGBH)尚未得到很好的理解。在本综述中,我们将阐述这种病症的定义、历史背景、诊断方法、当前可用的治疗选择以及经验性评估和治疗算法。