成年哮喘患者与哮喘-慢性阻塞性肺疾病重叠综合征患者之间，亚洲沙尘对肺功能影响的差异。
Differences in the effects of Asian dust on pulmonary function between adult patients with asthma and those with asthma-chronic obstructive pulmonary disease overlap syndrome.
作者信息
Watanabe Masanari, Noma Hisashi, Kurai Jun, Sano Hiroyuki, Ueda Yasuto, Mikami Masaaki, Yamamoto Hiroyuki, Tokuyasu Hirokazu, Kato Kazuhiro, Konishi Tatsuya, Tatsukawa Toshiyuki, Shimizu Eiji, Kitano Hiroya
机构信息
Department of Respiratory Medicine and Rheumatology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Japan.
Department of Data Science, The Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo, Japan.
出版信息
Int J Chron Obstruct Pulmon Dis. 2016 Jan 28;11:183-90. doi: 10.2147/COPD.S97460. eCollection 2016.
BACKGROUND
Asian dust (AD) exposure exacerbates pulmonary dysfunction in patients with asthma. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS), characterized by coexisting symptoms of asthma and chronic obstructive pulmonary disease, is considered a separate disease entity. Previously, we investigated the effects of AD on pulmonary function in adult patients with asthma. Here, we present the findings of our further research on the differences in the effects of AD exposure on pulmonary function between patients with asthma alone and those with ACOS.
METHODS
Between March and May 2012, we conducted a panel study wherein we monitored daily peak expiratory flow (PEF) values in 231 adult patients with asthma. These patients were divided into 190 patients with asthma alone and 41 patients with ACOS in this study. Daily AD particle levels were measured using light detection and ranging systems. Two heavy AD days (April 23 and 24) were determined according to the Japan Meteorological Agency definition. A linear mixed model was used to estimate the association between PEF and AD exposure.
RESULTS
Increments in the interquartile range of AD particles (0.018 km(-1)) led to PEF changes of -0.50 L/min (95% confidence interval, -0.98 to -0.02) in patients with asthma alone and -0.11 L/min (-0.11 to 0.85) in patients with ACOS. The PEF changes after exposure to heavy AD were -2.21 L/min (-4.28 to -0.15) in patients with asthma alone and -2.76 L/min (-6.86 to 1.35) in patients with ACOS. In patients with asthma alone, the highest decrease in PEF values was observed on the heavy AD day, with a subsequent gradual increase over time.
CONCLUSION
Our results suggest that the effects of AD exposure on pulmonary function differ between patients with asthma alone and ACOS, with the former exhibiting a greater likelihood of decreased pulmonary function after AD exposure.
背景
暴露于亚洲沙尘（AD）会加重哮喘患者的肺功能障碍。哮喘-慢性阻塞性肺疾病重叠综合征（ACOS），其特征为哮喘和慢性阻塞性肺疾病的症状共存，被视为一种独立的疾病实体。此前，我们研究了AD对成年哮喘患者肺功能的影响。在此，我们展示了关于单独哮喘患者与ACOS患者在AD暴露对肺功能影响方面差异的进一步研究结果。
方法
2012年3月至5月期间，我们进行了一项群组研究，监测了231名成年哮喘患者的每日呼气峰值流速（PEF）值。在本研究中，这些患者被分为190名单独哮喘患者和41名ACOS患者。使用光探测和测距系统测量每日AD颗粒水平。根据日本气象厅的定义确定了两个重度AD日（4月23日和24日）。采用线性混合模型估计PEF与AD暴露之间的关联。
结果
AD颗粒四分位间距增加（0.018 km⁻¹）导致单独哮喘患者的PEF变化为-0.50 L/min（95%置信区间，-0.98至-0.02），ACOS患者为-0.11 L/min（-0.11至0.85）。暴露于重度AD后，单独哮喘患者的PEF变化为-2.21 L/min（-4.28至-0.15），ACOS患者为-2.76 L/min（-6.86至1.35）。在单独哮喘患者中，重度AD日观察到PEF值下降幅度最大，随后随时间逐渐增加。
结论
我们的结果表明，单独哮喘患者与ACOS患者在AD暴露对肺功能的影响方面存在差异，前者在AD暴露后肺功能下降的可能性更大。
Zotero 插件