一名结肠癌甲状腺转移患者的KRAS突变与NRAS野生型报告：一例罕见病例报告
The Report of KRAS Mutation and NRAS Wild Type in a Patient with Thyroid Metastasis from Colon Cancer: a Rare Case Report.
作者信息
Payandeh Mehrdad, Sadeghi Masoud, Sadeghi Edris
机构信息
Dept. of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Iran J Pathol. 2016 Winter;11(1):71-5.
Colorectal cancer (CRC) metastasis to the thyroid gland is rare. Here we report a 45 yr-old man in western Iran referred to Hematology Clinic, Kermanshah City, Iran in March 2014 with complaint of exertional dyspnea, multi-nodular goiter as well as complaint of exertional dyspnea, and multi-nodular goiter. His history included a low anterior resection of rectum in 9 months ago for a high-risk stage II rectal adenocarcinoma. He did not show clinical signs of hyperthyroidism other than thyroid enlargement. In thyroid nodule the FNA cytology, pathology reported anaplastic thyroid malignancy. Pathologists reported final diagnosis of colorectal metastasis of thyroid gland. Then due to metastatic pattern of disease, his pathology was evaluated for RAS molecular assay. In the patients of metastatic CRC, RAS testing is the first step to identify those patients that could benefit from anti-EGFR monoclonal antibodies treatment.
结直肠癌（CRC）转移至甲状腺较为罕见。在此，我们报告一名45岁的伊朗西部男子，2014年3月因劳力性呼吸困难、多结节性甲状腺肿被转诊至伊朗克尔曼沙阿市血液学诊所。其病史包括9个月前因高危II期直肠腺癌接受低位前切除术。除甲状腺肿大外，他未表现出甲状腺功能亢进的临床症状。在甲状腺结节的细针穿刺活检（FNA）细胞学检查中，病理报告为未分化甲状腺恶性肿瘤。病理学家报告最终诊断为甲状腺的结直肠转移。然后，由于疾病的转移模式，对其病理进行了RAS分子检测。在转移性CRC患者中，RAS检测是识别那些可能从抗表皮生长因子受体（EGFR）单克隆抗体治疗中获益的患者的第一步。
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