Khotchava M, Lashkhi E, Jokhtaberidze T, Shalamberidze I
Tbilisi State Medical University; Ltd, Children's Infectious Diseases Clinical Hospital, Tbilisi, Georgia.
Georgian Med News. 2016 Jan(250):72-5.
Ceftriaxone is a third generation cephalosporin antibiotic and is one of the most often applicable parenteral drug, which has wide antimicrobial activity range. According to the literature gall bladder lithiasis is a complication which is described in the first days of the treatment with this antibiotic. The cases are seen mostly as undergdiagnosed conditions when ultrasound examination is performed due to the abdominal colics. The aim of the study was to observe Cholelithiasis in ceftriaxone-treated patients. Last year few cases of Cholelithiasis were observed in Children's Infectious Diseases Hospital. All of them were related to the dysentery treatment with ceftriaxone. All of the cases of Cholelithiasis were diagnosed at the beginning of the antibiotic therapy (in first 2-3 days of hospitalization). Gall bladder concernments/sludge were found accidentally. Cholelithiasis in these cases was transitory and in 2 weeks ultrasound investigation revealed no calculi/sludge in the gall bladder. Further findings are supposed to be analyzed on a bigger number of the patients. It is necessary to follow up with gall bladder concernments till their absolute resolution.
头孢曲松是第三代头孢菌素类抗生素,是最常用的注射用药物之一,具有广泛的抗菌活性范围。根据文献记载,胆囊结石是使用这种抗生素治疗最初几天出现的一种并发症。这些病例大多在因腹部绞痛进行超声检查时被漏诊。本研究的目的是观察接受头孢曲松治疗的患者中的胆石症情况。去年,在儿童传染病医院观察到几例胆石症病例。所有这些病例都与使用头孢曲松治疗痢疾有关。所有胆石症病例均在抗生素治疗开始时(住院的前2 - 3天)被诊断出来。胆囊病变/胆泥是偶然发现的。这些病例中的胆石症是暂时的,2周后的超声检查显示胆囊内没有结石/胆泥。后续需要对更多患者进行进一步分析。有必要对胆囊病变进行随访,直至其完全消失。