Harris M J, Gierz M, Lohr J B
University of California, San Diego.
Geriatrics. 1989 Dec;44(12):26-30.
Although there is no generally effective treatment for Alzheimer's disease, some common psychiatric symptoms associated with the disease, including depression, may respond to pharmacological intervention. Recognition of the depression requires a high index of suspicion from the primary care physician and caregivers and a history from family members or other caregivers. Several groups of medications, including tricyclic antidepressants, monoamine oxidase inhibitors, and psychostimulants, have been used for treatment of depression in dementia patients. Generally, Alzheimer's patients require lower dosages of medication and longer drug treatment trials than younger patients treated for depression.
虽然目前尚无针对阿尔茨海默病的普遍有效的治疗方法，但与该疾病相关的一些常见精神症状，包括抑郁，可能对药物干预有反应。对抑郁的识别需要初级保健医生和护理人员高度怀疑，并需要家庭成员或其他护理人员提供病史。包括三环类抗抑郁药、单胺氧化酶抑制剂和精神兴奋剂在内的几类药物已被用于治疗痴呆症患者的抑郁。一般来说，与治疗抑郁的年轻患者相比，阿尔茨海默病患者所需的药物剂量更低，药物治疗试验时间更长。
