肺炎克雷伯菌R质粒与重金属抗性、克雷伯菌素抗性、β-内酰胺酶产生及乳糖发酵的相关性
Association of R plasmids of Klebsiella pneumoniae with resistance to heavy metals, klebocin and beta lactamase production and lactose fermentation.
作者信息
Sikka R, Sabherwal U, Arora D R
出版信息
Indian J Pathol Microbiol. 1989 Jan;32(1):16-21.
One hundred and fifty clinical isolates of Klebsiella pneumoniae were studied for beta lactamase production, Klebocin production and resistance to antibiotics and metals. 97.3 and 82.7 per cent strains produced beta-lactamase and klebocin respectively. Resistance to arsenite, antimony, tellurite, mercury and silver was observed in 91,66,6, 47.7, 44.8 and 33.3 per cent respectively and to ampicillin, tetracycline and nalidixic acid in 93.3,60, 41.3, 34.4, 28.2, and 1.3 per cent respectively. Forty eight antibiotic and metal resistant strains were then conjugated with Escherichia coli 711 F-Lac-Nxr. Transferable drug resistance, metal ion resistance, beta lactamase production, klebocin production and lactose fermentation was seen in 30, 21, 10, 11 and 5 isolates respectively.
对150株肺炎克雷伯菌临床分离株进行了β-内酰胺酶产生、克雷伯菌素产生以及对抗生素和金属耐药性的研究。分别有97.3%和82.7%的菌株产生β-内酰胺酶和克雷伯菌素。分别有91%、66%、6%、47.7%、44.8%和33.3%的菌株对亚砷酸盐、锑、亚碲酸盐、汞和银耐药，分别有93.3%、60%、41.3%、34.4%、28.2%和1.3%的菌株对氨苄西林、四环素和萘啶酸耐药。然后将48株抗生素和金属耐药菌株与大肠杆菌711 F-Lac-Nxr进行接合试验。分别在30株、21株、10株、11株和5株分离株中观察到可转移的耐药性、金属离子耐药性、β-内酰胺酶产生、克雷伯菌素产生和乳糖发酵。
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