Raspollini Maria Rosaria, Castiglione Francesca, Cheng Liang, Montironi Rodolfo, Lopez-Beltran Antonio
Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy.
Histopathology and Molecular Diagnostics, Universital Hospital Careggi, Florence, Italy.
Pathol Res Pract. 2016 May;212(5):471-4. doi: 10.1016/j.prp.2016.01.001. Epub 2016 Jan 6.
We report a rare case of synchronous clear cell renal cell carcinoma and multilocular cystic renal cell neoplasia of low malignant potential in the same kidney. The tumors were seen incidentally in a 45-year-old man. Pathologic study revealed that the former tumor was nucleolar grade 2, and the multilocular cystic renal cell neoplasia of low malignant potential was nucleolar grade 1. At immunohistochemistry, the clear cells in both tumors were positive for CD10 and CA IX. Interestingly, these uncommon synchronous tumors showed a different KRAS/NRAS mutation analysis that was characterized by KRAS mutation at codon p.G12C in the clear cell renal cell carcinoma, while this mutation was not present in the case of multilocular cystic renal cell neoplasia of low malignant potential. NRAS mutation was not seen in any of the tumors.
我们报告了一例罕见的同一肾脏中同时存在透明细胞肾细胞癌和低恶性潜能多房囊性肾细胞肿瘤的病例。肿瘤在一名45岁男性中偶然发现。病理研究显示，前者肿瘤为核仁2级，而低恶性潜能多房囊性肾细胞肿瘤为核仁1级。免疫组化显示，两种肿瘤中的透明细胞CD10和CA IX均呈阳性。有趣的是，这些罕见的同步肿瘤显示出不同的KRAS/NRAS突变分析结果，其特征为透明细胞肾细胞癌中密码子p.G12C处的KRAS突变，而低恶性潜能多房囊性肾细胞肿瘤病例中不存在该突变。任何肿瘤中均未发现NRAS突变。
