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自我称重和简单饮食建议可减少超重和肥胖孕妇的产科并发症而不影响生活质量:一项随机对照试验。

Self-weighing and simple dietary advice for overweight and obese pregnant women to reduce obstetric complications without impact on quality of life: a randomised controlled trial.

机构信息

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Vic., Australia.

Mercy Hospital for Women, Heidelberg, Vic., Australia.

出版信息

BJOG. 2016 May;123(6):965-73. doi: 10.1111/1471-0528.13919. Epub 2016 Feb 14.

Abstract

OBJECTIVE

To determine the effect of serial weighing and dietary advice compared with standard antenatal care on obstetric outcomes.

DESIGN

Randomised controlled clinical trial.

SETTING

Australian tertiary obstetric hospital.

POPULATION

Three hundred and eighty-two overweight or obese non-diabetic pregnant women at less than 20 weeks gestation with a singleton pregnancy.

METHODS

Women were randomised to targeted, serial self-weighing and simple dietary advice, (intervention), or standard antenatal care (control).

MAIN OUTCOMES MEASURES

The primary outcome was a reduction in a composite of obstetric complications: gestational hypertension, pre-eclampsia, diabetes, assisted or caesarean birth, shoulder dystocia, severe perineal trauma, postpartum haemorrhage and maternal high dependency care. Secondary outcomes were gestational weight gain at 36 weeks' gestation, quality of life (QOL) and maternal serum levels of 28-week leptin, adiponectin and C-reactive protein (CRP).

RESULTS

There was no difference in the rate of the primary composite outcome of obstetric complications: 124/184 (67% control), 124/187 (66% intervention) [relative risk 0.98 (95% confidence interval (CI) 0.85-1.14)]. There was no difference in mean gestational weight gain [-0.9 kg (95% CI -2.0, 0.25)], QOL or leptin, adiponectin or CRP levels between intervention and control groups.

CONCLUSIONS

This low-cost, pragmatic intervention failed to prevent obstetric complications or modify maternal biochemistry or gestational weight gain in overweight or obese pregnant women. Participation in the study did not impair participants' QOL.

TWEETABLE ABSTRACT

Serial self-weighing and dietary advice failed to reduce obstetric complications in overweight pregnant women.

摘要

目的

比较连续称重和饮食建议与标准产前护理对产科结局的影响。

设计

随机对照临床试验。

地点

澳大利亚三级产科医院。

人群

382 名超重或肥胖且无糖尿病的妊娠 20 周以下的单胎孕妇。

方法

将女性随机分为目标明确、连续自我称重和简单饮食建议组(干预组)或标准产前护理组(对照组)。

主要观察指标

主要结局是减少产科并发症的综合发生率:妊娠高血压、先兆子痫、糖尿病、辅助分娩或剖宫产、肩难产、严重会阴创伤、产后出血和产妇高依赖护理。次要结局是 36 周时的妊娠体重增加、生活质量(QOL)和孕妇 28 周时的瘦素、脂联素和 C 反应蛋白(CRP)水平。

结果

两组产科并发症的主要综合结局发生率无差异:对照组 124/184(67%),干预组 124/187(66%)[相对风险 0.98(95%置信区间 0.85-1.14)]。干预组和对照组的平均妊娠体重增加[差值为-0.9kg(95%置信区间-2.0,0.25)]、QOL 或瘦素、脂联素或 CRP 水平均无差异。

结论

这种低成本、实用的干预措施未能预防超重或肥胖孕妇的产科并发症,也未能改变母体的生化指标或妊娠体重增加。参与研究并未损害参与者的 QOL。

推文摘要

连续自我称重和饮食建议未能降低超重孕妇的产科并发症发生率。

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