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与足细胞内结晶包涵体形成相关的肾轻链沉积:一例罕见病例报告

Renal Light Chain Deposition Associated with the Formation of Intracellular Crystalline Inclusion Bodies in Podocytes: A Rare Case Report.

作者信息

Wang Yuan-da, Dong Zhe-yi, Zhang Xue-guang, Zhang Wei, Yin Zhong, Qiu Qiang, Chen Xiang-mei

机构信息

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, China.

出版信息

Intern Med. 2016;55(4):369-73. doi: 10.2169/internalmedicine.55.4443. Epub 2016 Feb 15.

Abstract

We herein report the case of an elderly woman with bone pain and proteinuria as the main clinical manifestations. The patient was diagnosed with the IgG κ type of multiple myeloma. Her renal pathology consisted of widespread κ light chain protein deposition associated with the formation of large quantities of rod-like crystals in podocytes. This phenomenon is very rare. We explored the significance of this crystal formation via a detailed and descriptive analysis and also performed a literature review, thus providing data to increase the available information about this type of disease.

摘要

我们在此报告一例以骨痛和蛋白尿为主要临床表现的老年女性病例。该患者被诊断为IgG κ型多发性骨髓瘤。她的肾脏病理表现为广泛的κ轻链蛋白沉积,并伴有足细胞内大量棒状晶体形成。这种现象非常罕见。我们通过详细的描述性分析探讨了这种晶体形成的意义,并进行了文献综述,从而提供数据以增加关于此类疾病的可用信息。

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